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Lavrenko A.V.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kutsenko N.L.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kutsenko L.A.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Mamontova T.V.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kaĭdashev I.P.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

The action of metformin on the production of pro-inflammatory cytokines and insulin resistance (NF-kB signal pathway)

Authors:

Lavrenko A.V., Kutsenko N.L., Kutsenko L.A., Mamontova T.V., Kaĭdashev I.P.

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Journal: Problems of Endocrinology. 2012;58(2): 25‑28

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THE ACTION OF METFORMIN ON THE PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND INSULIN RESISTANCE (NF-KB SIGNAL PATHWAY)
THE ACTION OF METFORMIN ON THE PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND INSULIN RESISTANCE (NF-KB SIGNAL PATHWAY)

To cite this article:

Lavrenko AV, Kutsenko NL, Kutsenko LA, Mamontova TV, Kaĭdashev IP. The action of metformin on the production of pro-inflammatory cytokines and insulin resistance (NF-kB signal pathway). Problems of Endocrinology. 2012;58(2):25‑28. (In Russ.)

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Abstract:

The objective of the present study was to estimate the role of the NF-kB signal pathway in the realization of the anti-inflammatory and insulin-synthesizing activities of metformin in the patients presenting with coronary heart disease (CHD) associated with metabolic syndrome (MS). It was shown that the introduction of a one-month course of metformin therapy in the combined treatment of CHD resulted in the decreased production of pro-inflammatory cytokines, such as IL-1-beta, IL-6, IL-8, and TNF-alpha. Simultaneously, the serum C-peptide level decreased. These effects of metformin were mediated through the NF-kB-signal pathway. It is concluded that the inclusion of metformin in the combined treatment of coronary heart disease in the patients with metabolic syndrome prevent activation of NF-kB under the influence of endogeneous pro-inflammatory cytokines.

Keywords:

metformin
coronary heart disease
metabolic syndrome
insulin resistance
F-kB-signal pathway

Authors:

Lavrenko A.V.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kutsenko N.L.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kutsenko L.A.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Mamontova T.V.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

Kaĭdashev I.P.

NII geneticheskikh i immunologicheskikh osnov razvitiia patologii i farmakogenetiki Ukrainskoĭ meditsinskoĭ stomatologicheskoĭ akademii, Poltava

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