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Kit O.I.

National Medical Oncology Research Center

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Przhedetskaya V.Yu.

National Medical Oncology Research Center

Sagakyants A.B.

National Medical Research Centre of Oncology

Zlatnik E.Yu.

National Medical Research Centre of Oncology

Sharobaro V.I.

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia

Verbo E.V.

Petrovsky Russian Research Center of Surgery;
National Medical Research Center for Dentistry, Oral and Maxillofacial Surgery

Przhedetsky Yu.V.

National Medical Research Center of Oncology

Some features of cell-mediated immunity in patients with breast cancer undergoing breast implant reconstruction

Authors:

Kit O.I., Manturova N.E., Przhedetskaya V.Yu., Sagakyants A.B., Zlatnik E.Yu., Sharobaro V.I., Verbo E.V., Przhedetsky Yu.V.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2022;(1): 22‑31

DOI: 10.17116/plast.hirurgia202201122

Read: 2713 times

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Table of contents

SOME FEATURES OF CELL-MEDIATED IMMUNITY IN PATIENTS WITH BREAST CANCER UNDERGOING BREAST IMPLANT RECONSTRUCTION
SOME FEATURES OF CELL-MEDIATED IMMUNITY IN PATIENTS WITH BREAST CANCER UNDERGOING BREAST IMPLANT RECONSTRUCTION

To cite this article:

Kit OI, Manturova NE, Przhedetskaya VYu, et al. Some features of cell-mediated immunity in patients with breast cancer undergoing breast implant reconstruction. Plastic Surgery and Aesthetic Medicine. 2022;(1):22‑31. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia202201122

Подписка 2026 Пластическая хирургия и эстетическая медицина (Plastic Surgery and Aesthetic Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze the role of cell-mediated immunity in development of complications after breast reconstruction in patients with breast cancer.

MATERIAL AND METHODS

We studied cell-mediated immunity in wound and axillary fluid of 46 breast cancer patients within 7 days after implantation of a textured (TI) and polyurethane implant (PUI). Populations and subpopulations of immune cells were analyzed in peripheral blood and wound discharge using flow cytometry.

RESULTS

We found similar changes in cellular parameters for both implants. Higher content of cytotoxic CD8+-lymphocytes, NK-lymphocytes, and NKT-lymphocytes underlies development of scar tissue within the first postoperative week after TI implantation.

CONCLUSION

Regarding local immunity, TIs look more favorable compared to PUIs. PUI suppresses local immunity that can further increase the likelihood of local recurrence.

Keywords:

breast cancer
skin-sparing mastectomy
implants
capsular contracture
central and local cellular immunity

Authors:

Kit O.I.

National Medical Oncology Research Center

Manturova N.E.

Pirogov Russian National Research Medical University;
Institute of Plastic Surgery and Cosmetology

Przhedetskaya V.Yu.

National Medical Oncology Research Center

Sagakyants A.B.

National Medical Research Centre of Oncology

Zlatnik E.Yu.

National Medical Research Centre of Oncology

Sharobaro V.I.

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia

Verbo E.V.

Petrovsky Russian Research Center of Surgery;
National Medical Research Center for Dentistry, Oral and Maxillofacial Surgery

Przhedetsky Yu.V.

National Medical Research Center of Oncology

Received:

23.12.2021

Accepted:

10.01.2022

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References:

  1. Sostoyanie onkologicheskoj pomoshchi naseleniyu Rossii v 2019 godu. Kaprin AD, Starinsky VV, Shakhzadova AO, eds. M. 2020.
  2. Galich SP, Pinchuk VD. Rekonstruktivnaya khirurgiya grudi. M. 2011:264. 
  3. Butler PD, Nelson JA, Fischer JP, et al. Racial and age disparities persist in immediate breast reconstruction: An updated analysis of 48,564 patients from the 2005 to 2011 American College of Surgeons National Surgery Quality Improvement Program data sets. American Journal of Surgery. 2016;212(1):96-101.  https://doi.org/10.1016/j.amjsurg.2015.08.025
  4. Heidemann LN, Gunnarsson GL, Salzberg CA, Sorensen JA, Thomsen JB. Complications following Nipple-Sparing Mastectomy and Immediate Acellular Dermal Matrix Implant-based Breast Reconstruction — A Systematic Review and Meta-analysis. Plastic and Reconstructive Surgery — Global Open. 2018;6(1):e1625. https://doi.org/10.1097/GOX.0000000000001625
  5. Radovanovic Z, Ranisavljevic M, Radovanovic D, Vicko F, Ivkovic-Kapicl T, Solajic N. Nipple-sparing mastectomy with primary implant reconstruction in breast cancer patients: Surgical and oncological outcome. European Journal of Cancer. 2018;92:70-70.  https://doi.org/10.1159/000489317
  6. Shin BH, Kim BH, Kim S, Lee K, Choy YB, Heo CY. Silicone breast implant modification review: overcoming capsular contracture. Biomaterials Research. 2018;22:37. 
  7. Sobti N, Weitzman RE, Nealon KP, Jimenez RB, Gfrerer L, Mattos D, Ehrlichman RJ, Gadd M, Specht M, Austen WG, Liao EC. Evaluation of capsular contracture following immediate prepectoral versus subpectoral direct-to-implant breast reconstruction. Sci Rep. 2020;10(1):1137. https://doi.org/10.1186/s40824-018-0147-5
  8. Khokhlova OV, Przhedetskiy YuV, Zakharova NA, Borlakov AV, Przhedetskaya VYu. Oslozhneniya kozhesokhranyayushchej mastektomii s odnomomentnoj alloplastikoj u bol’nykh rakom molochnoj zhelezy. Sovremennye problemy nauki i obrazovaniya. 2015;5. 
  9. Woerdeman LA, Hage JJ, Hofland MM, Rutgers EJ. A prospective assessment of surgical risk factors in 400 cases of skin-sparing mastectomy and immediate breast reconstruction with implants to establish selection criteria. Plast Reconstr Surg. 2007;119(2):455-463.  https://doi.org/10.1097/01.prs.0000246379.99318.74
  10. Berry T, Brooks S, Sydow N, Djohan R, Nutter B, Lyons J, Dietz J. Complication rates of radiation on tissue expander and autologous tissue breast reconstruction. Ann Surg Oncol. 2010;17(Suppl 3):202-210.  https://doi.org/10.1245/s10434-010-1261-3
  11. Klopfleisch R, Jung F. The pathology of the foreign body reaction against biomaterials. J Biomed Mater Res A. 2017;105(3):927-940.  https://doi.org/10.1002/jbm.a.35958
  12. Kreuger J, Phillipson M. Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis. Nat Rev Drug Discov. 2016; 15(2):125.  https://doi.org/10.1038/nrd.2015.2
  13. Park RH, Pollock SJ, Phipps RP, Langstein HN, Woeller CF. Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment. Plastic and Reconstructive Surgery — Global Open. 2019;3:1-11.  https://doi.org/10.1097/GOX.0000000000002430
  14. Tolksdorf J, Horch RE, Grüner JS, Schmid R, Kengelbach-Weigand A, Schubert DW, Werner S, Schneidereit D, Friedrich O, Ludolph I. Size Matters — In Vitro Behaviour of Human Fibroblasts on Textured Silicone Surfaces With Different Pore Sizes. J Mater Sci Mater Med. 2020;31(2):23.  https://doi.org/10.1007/s10856-020-6360-5
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