The use of vascularized fibular autografts for repair of mandibular defects after injuries and resections with simultaneous microsurgical reconstruction has currently become a common surgical procedure. Preoperative planning, manufacturing of STL templates, autograft modeling, positioning the graft within the recipient area, microsurgical anastomosis are the main standard stages of microsurgical reconstruction. Classic removable prosthetics is perspectiveless in these patients due to mobility of the muscle sleeve or skin component over the bone and lack of anatomical conditions for qualitative denture fixation. Surgeons are confronted with fibula anatomy within the reconstructed jaws. Thickness of the muscle or skin sleeve over the bone graft is 3—30 mm. Therefore, installation of dental implants in 4—5 months after reconstruction is currently standard procedure for subsequent rehabilitation of these patients. Replacement is performed at the end of bone-to-implant integration period. We report single-stage dental implant placement into a vascularized fibular autograft with immediate loading of the implants by provisional prostheses (crowns manufactured with 3D virtual planning and printing). This approach significantly reduces recovery time in these patients.