The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Trifanov V.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Grishin N.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kornietskaya A.L.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia

Malushkova M.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Poluektov S.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kosogolov M.V.

Hertsen Moscow Oncology Research Institute

Possibilities of drug treatment for pseudomyxoma peritonei of appendiceal origin

Authors:

Trifanov V.S., Grishin N.A., Volchenko N.N., Kornietskaya A.L., Malushkova M.E., Poluektov S.I., Kosogolov M.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(6): 59‑64

DOI: 10.17116/onkolog20251406159

Read: 283 times

Buy for 300₽
Contact the author
Table of contents

POSSIBILITIES OF DRUG TREATMENT FOR PSEUDOMYXOMA PERITONEI OF APPENDICEAL ORIGIN
POSSIBILITIES OF DRUG TREATMENT FOR PSEUDOMYXOMA PERITONEI OF APPENDICEAL ORIGIN

To cite this article:

Trifanov VS, Grishin NA, Volchenko NN, Kornietskaya AL, Malushkova ME, Poluektov SI, Kosogolov MV. Possibilities of drug treatment for pseudomyxoma peritonei of appendiceal origin. P.A. Herzen Journal of Oncology. 2025;14(6):59‑64. (In Russ.)
https://doi.org/10.17116/onkolog20251406159

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Effi­cacy of chemoimmunotargeted therapy in patients with adva­nced non-small cell lung cancer in real clinical practice. P.A. Herzen Journal of Onco­logy. 2025;(3):63-70
Treatment of pseudomyxoma peri­toneum. (A review of the lite­rature and a clinical case). P.A. Herzen Journal of Onco­logy. 2025;(5):68-72
Prognostically unfa­vorable types of breast cancer. P.A. Herzen Journal of Onco­logy. 2025;(6):78-82
Combined treatment of patients with acute muscular tonic syndrome with dorsopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):70-77
Application of T-cells with chimeric anti­gen rece­ptor in the treatment of refractory autoimmune diseases. Russian Journal of Preventive Medi­cine. 2025;(7):106-110
The impact of combined immu­notherapy on the cellular composition of the tumor microenvironment in patients with gastric carcinoma. Russian Journal of Archive of Pathology. 2025;(4):24-30
Predictive immu­notherapeutic markers of adenocarcinomas and adenosquamous carcinoma of the cervix. Russian Journal of Archive of Pathology. 2025;(5):74-79
Endo­thelial function in patients with heart failure with preserved ejection fraction unde­rgoing multicomponent drug therapy. Russian Cardiology Bulletin. 2025;(4-2):135-144
Abstract:

The article is devoted to a rather rare pathology — mucinous tumor of the appendix with the formation of pseudomyxoma peritonei. There are currently no generally accepted clinical recommendations based on the results of randomized clinical trials regarding the treatment of this pathology. The role of drug therapy for pseudomyxoma peritonei is an understudied topic, but current evidence suggests that there is a lack of highly effective systemic therapy regimens. This paper demonstrates a clinical observation of the successful treatment of a patient with pseudomyxoma peritonei of appendiceal origin based on a personalized approach taking into account the molecular genetic features of the tumor.

Keywords:

pseudomyxoma peritonei (PMP)
intraoperative chemotherapy
drug therapy
personalized therapy
immunotherapy

Authors:

Trifanov V.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Grishin N.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Volchenko N.N.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kornietskaya A.L.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia

Malushkova M.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Poluektov S.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kosogolov M.V.

Hertsen Moscow Oncology Research Institute

Received:

23.03.2025

Accepted:

30.04.2025

Close metadata

References:

  1. Lin YL, Xu DZ, Li XB, et al. Consensuses and controversies on pseudomyxoma peritonei: a review of the published consensus statements and guidelines. Orphanet J Rare Dis. 2021;16(1):85.  https://doi.org/10.1186/s13023-021-01723-6
  2. Patrick-Brown TDJH, Carr NJ, Swanson DM, Larsen S, Mohamed F, Flatmark K. Estimating the Prevalence of Pseudomyxoma Peritonei in Europe Using a Novel Statistical Method. Ann Surg Oncol. 2021;28(1):252-257.  https://doi.org/10.1245/s10434-020-08655-8
  3. Sidorov DV, Grishin NA, Lozhkin MV, Troitskiĭ AA, Filonenko EV, Volchenko NN, Bolotina LV. Combined treatment of patients with pseudomyxoma peritonei. P.A. Herzen Journal of Oncology. 2019;8(2):81-87. (In Russ.). https://doi.org/10.17116/onkolog2019802181
  4. de Jong LAW, Elekonawo FMK, de Reuver PR, et al. Hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal carcinomatosis: a clinical pharmacological perspective on a surgical procedure. Br J Clin Pharmacol. 2019;85(1):47-58.  https://doi.org/10.1111/bcp.13773
  5. Moran B, Cecil T, Chandrakumaran K, Arnold S, Mohamed F, Venkatasubramaniam A. The results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in 1200 patients with peritoneal malignancy. Colorectal Dis. 2015;17(9):772-778.  https://doi.org/10.1111/codi.12975
  6. Taher R., Gray D., Ramage J. The quality of life of pseudomyxoma peritonei patients: a scoping review. European Journal of Cancer Care, 2024;(1): 8137209. https://doi.org/10.1155/2024/8137209
  7. Sommariva A., Tonello M., Rigotto G., et al. Novel Perspectives in Pseudomyxoma Peritonei Treatment. Cancers (Basel). 2021;13(23):5965. https://doi.org/10.3390/cancers13235965
  8. Kusamura S., Barretta F., Yonemura Y., et al. The Role of Hyperthermic Intraperitoneal Chemotherapy in Pseudomyxoma Peritonei After Cytoreductive Surgery. JAMA Surg. 2021;156(3):e206363. https://doi.org/10.1001/jamasurg.2020.6363
  9. Ma R., Lu D., Xue S., et al. Preoperative systemic chemotherapy does not benefit for appendiceal pseudomyxoma peritonei. ANZ J Surg. 2023;93(1-2):219-226.  https://doi.org/10.1111/ans.18041
  10. Govaerts K, Lurvink RJ, De Hingh IHJT, et al. Appendiceal tumours and pseudomyxoma peritonei: Literature review with PSOGI/EURACAN clinical practice guidelines for diagnosis and treatment. Eur J Surg Oncol. 2021;47(1):11-35.  https://doi.org/10.1016/j.ejso.2020.02.012
  11. Andersson Y, Fleten KG, Abrahamsen TW, et al. Anti-Angiogenic Treatment in Pseudomyxoma Peritonei-Still a Strong Preclinical Rationale. Cancers (Basel). 2021;13(11):2819. https://doi.org/10.3390/cancers13112819
  12. Li X, Liu G, Wu W. Progress in Biological Research and Treatment of Pseudomyxoma Peritonei. Cancers (Basel). 2024;16(7):1406. https://doi.org/10.3390/cancers16071406
  13. Murage NW, Ahmed NM, Underwood TJ, Walters ZS, Breininger SP. The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review. Cancer Metastasis Rev. 2023;42(1):335-359.  https://doi.org/10.1007/s10555-023-10088-0
  14. Dilly A, Honick BD, Lee YJ, Bartlett DL, Choudry HA. Rational application of targeted therapeutics in mucinous colon/appendix cancers with positive predictive factors. Cancer Med. 2020;9(5):1753-1767. https://doi.org/1002/cam4.2847
  15. Yan F, Lin Y, Zhou Q, Chang H, Li Y. Pathological prognostic factors of pseudomyxoma peritonei: comprehensive clinicopathological analysis of 155 cases. Hum Pathol. 2020;97:9-18.  https://doi.org/1016/j.humpath.2019.12.008
  16. Su J, Jin G, Votanopoulos KI, et al. Prognostic Molecular Classification of Appendiceal Mucinous Neoplasms Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020;27(5):1439-1447. https://doi.org/10.1245/s10434-020-08210-5
  17. Moaven O, Su J, Jin G, et al. Clinical Implications of Genetic Signatures in Appendiceal Cancer Patients with Incomplete Cytoreduction/HIPEC. Ann Surg Oncol. 2020;27(13):5016-5023. https://doi.org/10.1245/s10434-020-08841-8
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.