Global coagulation tests in pharmacological prophylaxis of venous thromboembolism in patients with prostate cancer after radical prostatectomy

Suvorin P.A.; Khronenko V.E.; Malanova A.S.; Vorobyov N.V.; Kalpinsky A.S.; Golovashchenko M.P.

doi:https://doi.org/10.17116/onkolog20251405141

Suvorin P.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0003-3370-2124

Khronenko V.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0001-8845-9913

Malanova A.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0003-4222-6959

Vorobyov N.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

ORCID: 0000-0001-5597-9533

Kalpinsky A.S.

P.Herzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0002-2209-3020

Golovashchenko M.P.

P.Herzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0001-7719-9976

Global coagulation tests in pharmacological prophylaxis of venous thromboembolism in patients with prostate cancer after radical prostatectomy

Authors:

Suvorin P.A., Khronenko V.E., Malanova A.S., Vorobyov N.V., Kalpinsky A.S., Golovashchenko M.P.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(5): 41‑46

DOI: 10.17116/onkolog20251405141

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To cite this article:

Suvorin PA, Khronenko VE, Malanova AS, Vorobyov NV, Kalpinsky AS, Golovashchenko MP. Global coagulation tests in pharmacological prophylaxis of venous thromboembolism in patients with prostate cancer after radical prostatectomy. P.A. Herzen Journal of Oncology. 2025;14(5):41‑46. (In Russ.)
https://doi.org/10.17116/onkolog20251405141

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

Использование инфографики авторами научных работ

OBJECTIVE

Determine the most appropriate coagulation test to monitor the effectiveness and safety of pharmacological prevention of VTE in patients with malignant neoplasm of the prostate gland after radical prostatectomy.

MATERIAL AND METHODS

The study included 44 patients diagnosed with prostate cancer. All patients underwent radical prostatectomy. Pharmacological prevention of VTE was performed with low-molecular-weight heparin (LWH) — calcium nadroparin in a standard dose, according to the recommendations of the American Society of Clinical Oncology (ASCO). Blood was collected for laboratory tests at 3 control points: the day of hospitalization, after surgery before the first administration of LWH, at the peak of the LWH effect 3—3.5 hours after subcutaneous administration.

RESULTS

The K interval of the thromboelastogram changed more frequently at all control points of the study. The maximum amplitude allowed us to identify a tendency to hypercoagulation before the start of pharmacological prophylaxis. The clot growth rate of the thrombodynamics test showed the most pronounced changes depending on the stage of treatment. The advantage of the thrombodynamics test is the known range of LMWH effectiveness, which makes this method more optimal and convenient to use.

CONCLUSION

Global coagulation tests during pharmacological prophylaxis of thrombosis in the postoperative period were more sensitive to changes in the state of hemostasis compared to activated partial thromboplastin time.

Keywords:

thrombosis

global coagulation tests

thromboelastography

thrombodynamics test

APTT

prostate cancer

Authors:

Suvorin P.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0003-3370-2124

Khronenko V.E.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0001-8845-9913

Malanova A.S.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

ORCID: 0000-0003-4222-6959

Vorobyov N.V.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

ORCID: 0000-0001-5597-9533

Kalpinsky A.S.

P.Herzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0002-2209-3020

Golovashchenko M.P.

P.Herzen Moscow Oncology Research Institute — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0001-7719-9976

Received:

24.04.2025

Accepted:

13.05.2025

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References:

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