Venous thromboembolic complications (VTEC) are a significant problem in various fields of surgery. Despite advances in its study and the availability of national, international and industry guidelines, VTEC still have a significant impact on treatment outcomes, length of hospital stay, overall costs and mortality of patients. An important aspect of VTEC prevention, according to the guidelines, is pharmacological prophylaxis that does not require laboratory monitoring. However, the results of numerous studies demonstrate the risks of this approach. Standard laboratory tests, determination of fibrinolytic and anti-Xa activity levels have known limitations and do not reflect the full range of physiological processes occurring in the coagulation system during the administration of anticoagulants, which leads to the need to search for more suitable monitoring tools. Global coagulation tests, on the contrary, provide a more comprehensive picture of the state of hemostasis at different periods of treatment and can be useful as laboratory control of the effectiveness of the therapy. The main efforts in scientific works are aimed at identifying the predictive potential of tests for a personalized approach to the prevention of VTEC, which is a pressing task. This review presents the results of an assessment of three global coagulation tests, demonstrating the possibility of their use as predictors of thrombosis and laboratory monitoring of VTEC prevention.