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Shatalov P.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Raygorodskaya M.P.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Shinkarkina A.P.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Murzaeva A.V.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Makarchuk V.M.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Averinskaya D.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Traspov A.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia;
Peoples’ Friendship University of Russia

Shegai P.V.

National Medical Research Center of Radiology of the Ministry of Health of Russia

The role of pharmacogenomics in personalized treatment of oncological diseases

Authors:

Shatalov P.A., Raygorodskaya M.P., Shinkarkina A.P., Murzaeva A.V., Makarchuk V.M., Averinskaya D.A., Traspov A.A., Kaprin A.D., Shegai P.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2023;12(6): 75‑81

DOI: 10.17116/onkolog20231206175

Views: 847

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To cite this article:

Shatalov PA, Raygorodskaya MP, Shinkarkina AP, et al. . The role of pharmacogenomics in personalized treatment of oncological diseases. P.A. Herzen Journal of Oncology. 2023;12(6):75‑81. (In Russ.)
https://doi.org/10.17116/onkolog20231206175

Подписка 2025 (P.A. Herzen Journal of Oncology)
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Malignant neoplasms have possible specific genetic characteristics that may determine the effectiveness of various treatments. Pharmacogenomics in oncology represents an advanced approach aimed at identifying the genetic features of tumors to select the most optimal therapeutic strategies. This review focuses on the role of pharmacogenomic approaches in the implementation of personalized treatment for oncological diseases. Pharmacogenomics is a cutting-edge field that relies not only on advances in next-generation sequencing but also on modern methods and algorithms for processing large volumes of data. This review discusses the relationship between pharmacogenomics and next-generation sequencing technologies, machine learning, and artificial intelligence. It emphasizes the importance of accumulating real-world data to enable the proper interpretation of identified genetic mutations and the use of this information in treatment personalization. The review also covers existing pharmacogenomic platforms and characterizes a domestically developed pharmacogenomic platform for making clinical decisions in oncology.

Keywords:

pharmacogenomics
personalized treatment
oncology
precision medicine

Authors:

Shatalov P.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Raygorodskaya M.P.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Shinkarkina A.P.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Murzaeva A.V.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Makarchuk V.M.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Averinskaya D.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Traspov A.A.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of Ministry of Russia;
Peoples’ Friendship University of Russia

Shegai P.V.

National Medical Research Center of Radiology of the Ministry of Health of Russia

Received:

12.09.2023

Accepted:

28.09.2023

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