Introduction. The surgical method is the main step in the treatment of breast cancer. One of the constant early postsurgery complications is lymphorrhea, which lasts in most cases 8—14 days, but in 30% of patients lasts 30—60 days. Effective management of the postsurgery period allows us to continue the combined treatment of breast cancer in a timely manner and affects the overall outcome of the treatment of malignant neoplasms. Aim of study — to increase the effectiveness of preventive measures to reduce the duration and volume of lymphorrhea. Material and methods. The results of surgical treatment of 144 patients with breast cancer were analyzed. Surgery by Madden was performed in 93 (64.6%) patients, by Paty — in 29 (20.1%), radical breast resection — in 22 (15.3%). The factors affecting the volume and duration of lymphorrhea (age, body mass index, size and histological type of tumor, concomitant pathology, type of surgery) were studied. All patients were divided into 5 groups depending on the method used for the prevention of postoperative lymphorrhea: reducing the power of electric current during tissue dissection, using axillary fossa plastic surgery, fixing skin flaps to the chest wall. Results. Reducing the power of the generator during tissue dissection significantly reduces the volume of lymph flow (p=0.026). The use of axillary fossa plastic surgery and fixation of skin flaps to the chest helps to reduce the amount of lymphorrhea in the postoperative period (p=0.041). The optimal combination to reduce the volume and duration of lymphorrhea is the use of a low-energy regime of an electrocoagulator (25 W), axillary fossa myoplastic, and chest flap fixation (pairwise posterior comparisons of patient groups were used with help of Newman-Cales method (p=0.009)). Conclusions. The combination of methods, found for prevention, reduces the duration of lymphatic drainage and the length of stay of patients in the hospital.