Introduction. Hepatic dysfunction in patients with digestive tract tumors can lead not only to protein-energy malnutrition in the postoperative period, but also to obvious endotoxemia. Therefore, it is very important to clarify a metabolic (nutritional) risk for determining whether extensive liver resections can be performed. Objective — to study the impact of incorporation of remaxol into a nutritional support regimen for patients with digestive tract tumors after hemihepatectomy. Subjects and methods. The clinical and laboratory data were analyzed in 11 patients divided into 2 groups according to the treatment regimen: 1) 6 patients received traditional nutritional correction with detox diet; 2) 5 patients had an infusion-diet program including remaxol infused at a rate of 40 drops/min for 6 days. Nutritional deficiency was evaluated according to the alimentation-volemic diagnosis criteria and the nutrition risk index; sarcopenia was identified using bioimpedance analysis; the hematological indices of intoxication (Krebs index, adaptation index by L.Kh. Garkavi, and white blood cell/erythrocyte sedimentation rate ratio) were calculated. Hepatological parameters (total protein, albumin, bilirubin, alanine aminotransferase, lactate dehydrogenase, blood urea and creatinine levels and electrolyte composition) were determined by conventional techniques. The severity of the condition was evaluated, by applying the Acute Physiology and Chronic Health Disease Classification System II (APACHE II); quality of life was assessed by the Eastern Cooperative Oncology Group (ECOG) Performance Status Scale. Results. Remaxol with complex detoxifying and antihypoxic properties, which was incorporated into combined detox diet programs, enhances the efficiency of therapy: the alanine aminotransferase and bilirubin levels were restored more effectively and the hematological indices of intoxication (Krebs index and Garkavi adaptation index) were especially indicative. Leukocytosis and the degree of nutritional risk decreased more intensively and the quality of life became better. Conclusions. Combined nutritional support programs additionally incorporating hepatotropic components are much more effective than traditional detox diet programs.