Objective — to increase the efficiency of detection, differential diagnosis, and timely treatment of early breast diseases accompanied by a microcalcification cluster, which are a reflection of epigenetic reprogramming. Subject and methods. A total of 124 patients with non-palpable cancer as a local microcalcification cluster were comprehensively surveyed using up-to-date non-invasive and invasive radiographic and ultrasound technologies. Results. Ductal carcinoma in situ and microinvasive carcinoma were found in 55.6% of cases, benign diseases, including proliferative fibrocystic mastopathy, were detected in 30.1%; fibrosclerosis in 22.3%, adenosis in 20.3%, etc. Specific differential-diagnostic symptom complexes based on clinical, radiological, sonographic and pathologic manifestations of this group of diseases were created according to the results of an analysis of the examination and interdisciplinary interaction of radiation diagnosticians, oncologists, and molecular biologists, by using highly informative technologies of early diagnosis. Adequate conservative treatments for benign breast diseases, which could timely prevent the development of cancer, were substantiated. Conclusion. The presented interdisciplinary approach to covering the problem of breast dysplasias of various nature, accompanied by microcalcinations, will be able to more efficiently use the latest technologies for the prevention of breast cancer.