Molecular cancer biology and prospects for effective therapy

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Due to recent fundamental discoveries, the concept of carcinogenesis, the development of metastatic disease, the patterns of a recurrent malignant process, and the mechanisms involved in the development of resistance has undergone considerable changes. The pooled currently accumulated information allow one to confidently assert that cancer progresses due to the emergence of clones owing to oncogene mutations or epigenetic modifications recorded in the stem cells. The understanding of dormancy, which has become accessible in oncology, the disclosure of its mechanisms, and the role of the inflammatory microenvironment must make a considerable contribution to the development of effective systemic therapy.

Keywords:

carcinogenesis

metastasis

metastatic niche

dormancy

cancer stem cells

inflammation

tumor growth rate model

epigenetics

antitumor therapy

Authors:

Ashrafian L.A.

FGBU "Rossiĭskiĭ nauchnyĭ tsentr rentgenoradiologii" Minzdrava RF, Moskva

Kiselev V.I.

Acad. V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia

Kuznetsov I.N.

Moscow State University of Medicine and Dentistry Named After A.I. Evdokimov

Muizhnek E.L.

Russian X-ray Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Gerfanova E.V.

Russian X-ray Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Vashakmadze S.L.

Russian X-ray Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

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