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Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Khomyakov V.M.

Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia

Ryabov A.B.

Hertsen Moscow Oncology Research Center, Moscow, Russia

Bolotina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Ivanov A.V.

Republican Bureau of Forensic Medical Examination of the Ministry of Health of Chuvashia, Cheboksary, Chuvash Republic, Russia

Cheremisov V.V.

Thoracoabdominal Surgical Department of P.A. Gertsen Moscow Research Oncology Institute, Health Ministry of the Russian Federation

Kolobaev I.V.

Hertsen Moscow Oncology Research Center, Moscow, Russia

Chaika A.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, P.A. Herzen Federal Medical Research Center, Ministry of Health of Russia, Moscow

Sobolev D.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kramskaia L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute, Branch, P.A. Herzen Federal Medical Research Center, Ministry of Health of Russia, Moscow

Pressurized intraperitoneal aerosol chemotherapy in patients with disseminated gastric cancer

Authors:

Kaprin A.D., Khomyakov V.M., Ryabov A.B., Bolotina L.V., Ivanov A.V., Cheremisov V.V., Kolobaev I.V., Chaika A.V., Sobolev D.D., Kramskaia L.V., Utkina A.B.

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Journal: P.A. Herzen Journal of Oncology. 2016;5(2): 12‑18

DOI: 10.17116/onkolog20165212-18

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To cite this article:

Kaprin AD, Khomyakov VM, Ryabov AB, et al. . Pressurized intraperitoneal aerosol chemotherapy in patients with disseminated gastric cancer. P.A. Herzen Journal of Oncology. 2016;5(2):12‑18. (In Russ.)
https://doi.org/10.17116/onkolog20165212-18

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Objective — to evaluate the efficiency and safety of pressurized intraperitoneal aerosol chemotherapy (PIAC) for the palliative treatment of patients with carcinomatosis in gastric cancer. Subjects and methods. The patients were treated in accordance with the adopted protocol. On postoperative days 1 and 3, the safety was evaluated through physical examination and blood collection for routine laboratory tests. The investigation enrolled 18 patients (6 men and 12 women). Their mean age was 54.2 years. Results. Three cases were recorded to have adverse events: nausea without vomiturition in 2 (11.1%) cases during 2 days after PIAC and iatrogenic diaphragmatic perforation in 1 patient during peritoneal biopsy. The median survival was 10 months; one-year survival rate was 53%. At the same time, 9 patients are alive and continue to participate in the investigation during the first year of follow-up. Conclusion. PIAC is a simple, low-invasive, and safe palliative treatment in patients with disseminated carcinomatosis in gastric cancer.

Keywords:

gastric cancer
peritoneal carcinomatosis
intraperitoneal chemotherapy

Authors:

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Khomyakov V.M.

Military medical unit, Golytsino, Moscow region, Russia, P.A. Gertsen Moscow scientific and research oncologic institute, National medical research center of radiology trust, Moscow, Russia

Ryabov A.B.

Hertsen Moscow Oncology Research Center, Moscow, Russia

Bolotina L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Ivanov A.V.

Republican Bureau of Forensic Medical Examination of the Ministry of Health of Chuvashia, Cheboksary, Chuvash Republic, Russia

Cheremisov V.V.

Thoracoabdominal Surgical Department of P.A. Gertsen Moscow Research Oncology Institute, Health Ministry of the Russian Federation

Kolobaev I.V.

Hertsen Moscow Oncology Research Center, Moscow, Russia

Chaika A.V.

P.A. Herzen Moscow Oncology Research Institute, Branch, P.A. Herzen Federal Medical Research Center, Ministry of Health of Russia, Moscow

Sobolev D.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Kramskaia L.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute, Branch, P.A. Herzen Federal Medical Research Center, Ministry of Health of Russia, Moscow

List of references:

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  2. Kaprin A, Sobolev D, Khomyakov V, Bolotina L, Ryabov A, Khoronenko V, Kolobaev I, Shemetova M, Kramskaya L, Ivanov A. Results of combined treatment using hyperthermic intraoperative intraperitoneal chemotherapy in patients with locally advanced and disseminated gastric cancer. Onkologiya. Zhurnal im. P.A. Gertsena. 2014;3(6):5-13. (In Russ.)
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