Objective — to develop different techniques of the oncoplastic breast resections used for the appropriate locations of breast cancer (BC) and to assess the obtained surgical, oncological, and aesthetic results. Subjects and methods. A total of 331 organ-sparing operations for Stages 0—IV breast cancer were performed in 2013 to 2015. The patients’ mean age was 54.7 years; their menstrual periods were preserved in 87 patients; there were 244 menopausal women. Classical radical breast resections were done in 154 cases; cancer plastic resections in various modifications were performed in 177 patients. The choice of a specific procedure for organ-sparing surgery depended on the location, sizes, immunohistochemical and histological type of a tumor, tumor-to-breast size ratio, and a patient’s desire. During oncoplastic breast resections, contralateral reduction mammoplasty was simultaneously carried out in 50 (28%) patients. Results. There were marginal skin necroses during cancer plastic resections to form an inverted T scar in 6 (1.8%) cases and marginal areolar necroses in 2 (0.6%) cases. During 2.5 years, local recurrences were found in 3 (0.9%) patients, which required mastectomy with single-stage reconstruction. Cosmetic results were noted to be excellent, good, and satisfactory in 60, 35, and 5% of cases, respectively. Conclusion. Oncoplastic breast resection is an ablastic operation with a good cosmetic result; it is accompanied by the least injury rates, the time of surgery, blood loss, and a postoperative rehabilitation period versus radical mastectomy with single-stage reconstruction; it is also an adequate alternative to radical mastectomy with reconstruction in the proper selection of patients with BC and leads to a prompter psychological recovery in patients due to the preserved sensation of the organ’s integrity.