Modern treatment options for children with peritoneal carcinomatosis: literature review

Gunyakov S.O.; Dzasokhov A.S.; Rykov M.Yu.

doi:https://doi.org/10.17116/endoskop20263202173

Gunyakov S.O.

Moscow Regional Oncological Dispensary, Balashikha, Russia;
Burnazyan Federal Medical Biophysical Center, Moscow, Russia

ORCID: 0009-0002-4796-8249

Dzasokhov A.S.

Moscow Regional Oncological Dispensary, Balashikha, Russia

ORCID: 0000-0003-4977-3533

Rykov M.Yu.

Russian State Social University, Moscow, Russia;
Central Research Institute of Informatization and Healthcare Organization, Moscow, Russia

ORCID: 0000-0002-8398-7001

Modern treatment options for children with peritoneal carcinomatosis: literature review

Authors:

Gunyakov S.O., Dzasokhov A.S., Rykov M.Yu.

More about the authors

Journal: Endoscopic Surgery. 2026;32(2): 73‑78

DOI: 10.17116/endoskop20263202173

Read: 310 times

Contact the author

Table of contents

To cite this article:

Gunyakov SO, Dzasokhov AS, Rykov MYu. Modern treatment options for children with peritoneal carcinomatosis: literature review. Endoscopic Surgery. 2026;32(2):73‑78. (In Russ.)
https://doi.org/10.17116/endoskop20263202173

Подписка 2026 Эндоскопическая хирургия (Endoscopic Surgery)

Использование инфографики авторами научных работ

BACKGROUND

Peritoneal carcinomatosis in children is rare and occurs as a result of the intraperitoneal spread of tumors. Peritoneal carcinomatosis is characterized by extensive damage to the peritoneum, metastases can spread to the abdominal and retroperitoneal lymph nodes, as well as to parenchymal organs such as the liver and spleen. In adult patients, cytoreductive surgery followed by HIPEC and PIPAC techniques can prolong overall and relapse-free survival. The review examines the prospects of using this technology in children.

OBJECTIVE

To evaluate the prospects of using HIPAC and PIPAC in children.

MATERIAL AND METHODS

A preliminary review of scientific papers published in 2000—2025 in the bibliographic and abstract databases of peer—reviewed scientific literature SinceDirect, Scopus, RSCI was conducted using the following keywords: peritoneal carcinomatosis in children, peritoneal carcinomatosis in adults, PIPAC, HIPEC in children. 8 publications devoted to the effectiveness of treatment of patients with peritoneal carcinomatosis were selected.

RESULTS

The main method used in children is HIPEC. The incidence of complications and the effectiveness of treatment are similar to the results in adults. However, this procedure is not possible for all patients. In such cases, the use of PIPEC is advisable, which ensures tumor regression and a long relapse-free period.

CONCLUSION

Peritoneal carcinomatosis is a serious problem and requires the development of modern standardized treatment approaches. HIPEC and PIPEC are self-contained methods and can be used interchangeably in certain cases. However, it is necessary to develop a protocol that will allow stratification of patients at different stages of treatment in order to select the appropriate method in a particular case.

Keywords:

oncology

chemotherapy

PIPEC

HIPEC

peritoneal carcinomatosis

abdominal tumors

Authors:

Gunyakov S.O.

Moscow Regional Oncological Dispensary, Balashikha, Russia;
Burnazyan Federal Medical Biophysical Center, Moscow, Russia

ORCID: 0009-0002-4796-8249

Dzasokhov A.S.

Moscow Regional Oncological Dispensary, Balashikha, Russia

ORCID: 0000-0003-4977-3533

Rykov M.Yu.

Russian State Social University, Moscow, Russia;
Central Research Institute of Informatization and Healthcare Organization, Moscow, Russia

ORCID: 0000-0002-8398-7001

Received:

01.04.2025

Accepted:

06.05.2025

Close metadata

References:

Badru F, Saxena S, Munoz-Abraham AS, Guzman MA, Bansal S, Chatoorgoon K. Peritoneal Nodules in a Pediatric Patient with Benign Teratoma. A Case Report and Review of Literature. J Pediatr Adolescent Gynecol. 2018;31(6):632-636. https://doi.org/10.1016/j.jpag.2018.07.001
Bautista F, Elias D, Pasqualini C, Valteau-Couanet D, Brugières L. (2014). Hyperthermic intraperitoneal chemotherapy after cytoreductive surgery for the treatment of peritoneal carcinomatosis in pediatric solid malignancies: a single institution experience. J Pediatr Surg. 2014;49(8):1276-1279. https://doi.org/10.1016/j.jpedsurg.2014.01.054
Fields AC, Lu PW, Li GZ, Welten V, Jolissaint JS, Vierra BM, Saadat L v, Larson AC, Atkinson RB, Melnitchouk N. Current practices and future steps for hyperthermic intraperitoneal chemotherapy. Curr Problems Surg. 2020;57(3):100727. https://doi.org/10.1016/j.cpsurg.2019.100727
Gangopadhyay AN, Rajeev R, Sharma SP, Upadhyaya VD, Arya NC, Kumar V, Gopal SC. Anterior Intratumoural Chemotherapy: A Newer Modality of Treatment in Advanced Solid Tumours in Children. Asian J Surg. 2008;31(4):225-229. https://doi.org/10.1016/S1015-9584(08)60092-5
James KM, Bogue CO, Murphy AJ, Navarro OM. Peritoneal Malignancy in Children: A Pictorial Review. Canadian Assoc Radiologists J. 2016;67(4):402-408. https://doi.org/10.1016/j.carj.2016.03.003
Morowitz M, Huff D, von Allmen D. Epithelial ovarian tumors in children: A retrospective analysis. J Pediatr Surg. 2003;38(3):331-335. https://doi.org/10.1053/jpsu.2003.50103
Msika S, Gruden E, Sarnacki S, Orbach D, Philippe-Chomette P, Castel B, Sabaté J-M, Flamant Y, Kianmanesh R. Cytoreductive surgery associated to hyperthermic intraperitoneal chemoperfusion for desmoplastic round small cell tumor with peritoneal carcinomatosis in young patients. J Pediatr Surg. 2010;45(8):1617-1621. https://doi.org/10.1016/j.jpedsurg.2010.03.002
Nakamoto S, Tanaka K, Watanabe E, Takeda N, Nakamura T, Kumamoto Y. Colorectal cancer with peritoneal carcinomatosis in a teenager. J Pediatr Surg Case Reports. 2020;54:101385. https://doi.org/10.1016/j.epsc.2020.101385
Orbach D, André N, Brecht IB, López Almaraz R, Ben-Ami T, Vermersch S, Carton M, Virgone C, Bisogno G, Schneider DT, Bajciova V, Reguerre Y, Galateau-Salle F, Stachowicz-Stencel T, Dvir R, Rees H, Bien E, Ferrari A, ben Arush M. Mesothelioma in children and adolescents: the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) contribution. Eur J Cancer. 2020;140:63-70. https://doi.org/10.1016/j.ejca.2020.09.011
Reingruber B, Boettcher MI, Klein P, Hohenberger W, Pelz JOW. Hyperthermic intraperitoneal chemoperfusion is an option for treatment of peritoneal carcinomatosis in children. J Pediatr Surg. 2007;42(9):e17-e21. https://doi.org/10.1016/j.jpedsurg.2007.06.009
Sorrentino L, Serra F, Cabry F, de Julis S, Barbieri E, Girardis M, Ceccarelli PL, Gelmini R. Cytoreductive surgery and HIPEC in a 14 years old patient with peritoneal recurrence of adenocarcinoma of the right colon. Int J Surg Case Reports. 2019;57:118-121. https://doi.org/10.1016/j.ijscr.2019.02.046
Tamura T, Yamataka A, Murakami T, Okada Y, Kobayashi H, Ohshiro K, Lane GJ, Miyano T. Primary Mucinous Cystadenoma Arising from Behind the Posterior Peritoneum of the Descending Colon in a Child: A Case Report. Asian J Surg. 2003;26(4):237-239. https://doi.org/10.1016/S1015-9584(09)60313-4
Zmora O, Hayes-Jordan A, Nissan A, Kventsel I, Newmann Y, Itskovsky K, Ash S, Levy-Mendelovich S, Shinhar D, Ben-Yaakov A, Toren A, Bilik R. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for disseminated intra-abdominal malignancies in children — a single-institution experience. J Pediatr Surg. 2018;53(7):1381-1386. https://doi.org/10.1016/j.jpedsurg.2017.09.014
Di Giorgio A, Macrì A, Ferracci F, Robella M, Visaloco M, De Manzoni G, Sammartino P, Sommariva A, Biacchi D, Roviello F, Pastorino R, Pires Marafon D, Rotolo S, Casella F, Vaira M. 10 Years of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A Systematic Review and Meta-Analysis. Cancers (Basel). 2023;15(4):1125. https://doi.org/10.3390/cancers15041125
Dzasochov AS, Kostin AA, Astashov VL, Andreeva MA, Turiev AB, Urazovskii NYu. Pressurized intraperitoneal aerosolized chemotherapy clinical efficacy in the combined treatment of newly diagnosed ovarian cancer with peritoneal carcinomatosis and ascites. Research and Practical Medicine Journal. 2024;11(4):36-45. (In Russ.). https://doi.org/10.17709/2410-1893-2024-11-4-3
Valenzuela-Méndez B, Bouillin A, Guiñez-Robertson G, de Meeus G, Quénet F, Sgarbura O. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) evaluation of safety and feasibility in advanced ovarian cancer. Experience of an oncological expert center. Int J Gynecol Cancer. 2023;33: A324-A325. https://doi.org/10.1136/ijgc-2023-ESGO.680
Vizzielli G, Giudice MT, Nardelli F, Costantini B, Salutari V, Inzani FS, Zannoni GF, Chiantera V, di Giorgio A, Pacelli F, Fagotti A, Scambia G. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Applied to Platinum-Resistant Recurrence of Ovarian Tumor: A Single-Institution Experience (ID: PARROT Trial). Ann Surg Oncol. 2024;31(2):1207-1216. https://doi.org/10.1245/s10434-023-14648-0
Akhaladze DG, Rabaev GS, Grachev NS. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in children. Pediatric Hematology/Oncology and Immunopathology. 2019;18(4):118-126. (In Russ.). https://doi.org/10.24287/1726-1708-2019-18-4-118-126
Akhaladze D, Rabaeva L, Krivonosov A, Merkulov N, Talypov S, Tverdov I, Uskova N, Rabaev G, Grachev N. Laparoscopic cytoreductive surgery with hyperthermic chemoperfusion of the abdominal cavity for peritoneal sarcomatosis in a child with embryonal rhabdomyosarcoma. The first Russian experience in pediatric practice. Russian Journal of Pediatric Hematology and Oncology. 2023;9:96-101. https://doi.org/10.21682/2311-1267-2022-9-4-96-101
Ryabov AB, Vrublevsky SG, Shmyrov OS, Polushkina OB, Trunov VO, Koritsky AV, Kurenkov IV. Thoracoabdominal oncosurgery: 2 years of experience at the Morozov hospital. Oncopediatrics. 2015;2(3):331-332. (In Russ.).
Ryabov AB, Poddubny IV, Trunov VO. Laparoscopic surgery for neurogenic tumors in children. Russian Bulletin of Pediatric Surgery, Anesthesiology, and Resuscitation. 2021;11(S):119. (In Russ.).
Gilly FN, Carry PY, Sayag AC, et al. Regional chemotherapy (with mitomycin C) and intra-operative hyperthermia for digestive cancers with peritoneal carcinomatosis. Hepatogastroenterology. 1994;41:124-129.
Cho M, Kim HS, Jung M, Hyung WJ. Perioperative intraperitoneal plus systemic chemotherapy and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for gastric cancer: phase Ib/II single-arm prospective study. J Gastrointest Surg. 2024;28(7):1095-1103. https://doi.org/10.1016/j.gassur.2024.04.030
Graham I, Boston A, Hayward R, Berri R. Outcomes following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancies: 10 Year experience. Am J Surg. 2024;230: 78-81. https://doi.org/10.1016/j.amjsurg.2024.01.031
Hassan S, Dritsas S, O’Dwyer ST, Aziz O, Sutton P, Wang X, Fish R, Renehan AG, Wilson M, Selvasekar C, Clouston H, Wild J, Mathur M. Open versus Closed technique for administration of heated intraperitoneal chemotherapy (HIPEC): Morbidity and Mortality outcomes from a high-volume centre. Eur J Surg Oncol. 2023;49(9):106924. https://doi.org/10.1016/j.ejso.2023.04.023
Kim JH, Park E, Park SY, Lim MC. A randomized, multicenter, open-label phase III trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in platinum-resistant recurrent ovarian cancer: a rationale and study design of the KOV-HIPEC-02 trial. Int J Gynecol Cancer. 2025;35(4):101630. https://doi.org/10.1016/j.ijgc.2025.101630
Pelc Z, Sędłak K, Endo Y, van Sandick J, Gisbertz S, Pera M, Baiocchi GL, Morgagni P, Framarini M, Hoelscher A, Moenig S, Kołodziejczyk P, Gockel I, Piessen G, Eveno C, da Costa PM, Davies A, Baker C, Allum W, Rawicz-Pruszyński K. Hyperthermic intraperitoneal chemotherapy (HIPEC) for gastric cancer with peritoneal metastasis — Joint analysis of European GASTRODATA and American national cancer database. Am J Surg. 2025;242:116235. https://doi.org/10.1016/j.amjsurg.2025.116235
Khomyakov VM, Ryabov AB, Utkina AB, et al. Results of systemic chemotherapy in combination with pressurized intraperitoneal aerosol chemotherapy in patients with gastric cancer and synchronous peritoneal carcinomatosis. P.A. Herzen Journal of Oncology. 2022;11(2):5-12. (In Russ.). https://doi.org/10.17116/onkolog2022110215