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Kovtun N.A.

Clinical Hospital No. 1 of Department of President Affairs, Moscow

Savelyeva M.I.

Russian Medical Academy of Continuous Professional Education

Trophimenko A.V.

Central State Medical Academy of President Affairs

Alexanin S.S.

Russian Center for Emergency and Radiation Medicine named after A.M. Nikiforov EMERCOM of Russia

Boyarincev V.V.

Central State Medical Academy of President Affairs

Diagnostic and prognostic value of protein markers determination of brain damage in mild traumatic brain injuries

Authors:

Kovtun N.A., Savelyeva M.I., Trophimenko A.V., Alexanin S.S., Boyarincev V.V.

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Journal: Laboratory Service. 2021;10(2): 28‑33

DOI: 10.17116/labs20211002128

Views: 745

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To cite this article:

Kovtun NA, Savelyeva MI, Trophimenko AV, Alexanin SS, Boyarincev VV. Diagnostic and prognostic value of protein markers determination of brain damage in mild traumatic brain injuries. Laboratory Service. 2021;10(2):28‑33. (In Russ.)
https://doi.org/10.17116/labs20211002128

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Easy traumatic brain injury (TBI) also known as concussion is a traumatic force to the brain leading to disruption of its functioning. Symptomatology associated with a concussion is primarily functional in nature since the standard brain imaging methods do not reveal structural abnormalities; however postmortem analysis of brains of patients who have suffered a moderate head injury recently but deaths from non-traumatic causes showed signs of damage to the axons. Diagnostic and prognostic tools for risk stratification in patients with mild TBI (mTBI) is limited in the early stages after injury. Currently, there is a critical need in testing and implementation of new laboratory diagnostic tools in mild head injury in clinical practice.

THE AIM OF THE STUDY

To investigate biochemical markers of cellular damage to the brain for the development of an algorithm for clinical and diagnostic verification of mild traumatic brain injuries.

MATERIAL AND METHODS

A prospective comparative study included 121 people in the three comparison groups. Measurement of the level of examined biomarkers in the dynamics was carried out using the methods of ELISA. Measurement of the main laboratory indicators of the general condition of the patient was carried out using automatic analyzers. All statistical calculations were performed by using SPSS version 20.0 and GraphPad Prism version 5.0 (GraphPad Inc).

THE STUDY RESULTS

It was found that the determination of the concentration of Tau- (with the exception of Tau3), GFAP- and pNF-proteins in dynamic measurement improves the diagnosis of cellular damage to the brain in mild TBI, regardless of the computer tomography (CT) scan results, and increases the risk of an adverse prognosis. An algorithm for the verification of mild TBI was developed on the basis of the determination of Tau-, GFAP- and pNF-blood proteins in dynamics.

CONCLUSION

The determination of the concentration of Tau-, GFAP-, and pNF-proteins can be considered as diagnostic and prognostic biomarkers of cellular damage to the brain regardless of the CT results.

Keywords:

cellular biomarkers of brain injury
Tau-protein
GFAP protein
pNF-protein
brain traumatic injury
mTBI

Authors:

Kovtun N.A.

Clinical Hospital No. 1 of Department of President Affairs, Moscow

Savelyeva M.I.

Russian Medical Academy of Continuous Professional Education

Trophimenko A.V.

Central State Medical Academy of President Affairs

Alexanin S.S.

Russian Center for Emergency and Radiation Medicine named after A.M. Nikiforov EMERCOM of Russia

Boyarincev V.V.

Central State Medical Academy of President Affairs

Received:

20.02.2021

Accepted:

01.04.2021

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