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Ptitsyna A.I.

Department of Clinical Laboratory Diagnostics North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Stuf I.Yu.

Department of Clinical Laboratory Diagnostics North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Kurapeev I.S.

Mechnikov North-Western State Medical University of Ministry of Health of the Russia, St. Petersburg, Russia

Kozlov A.V.

Kraevaia klinicheskaia bol'nitsa, Barnaul

Can urine lipocalin-2 be a marker of acute kidney injury in cardiac surgical patients with an initially normal glomerular filtration rate?

Authors:

Ptitsyna A.I., Stuf I.Yu., Kurapeev I.S., Kozlov A.V.

More about the authors

Journal: Laboratory Service. 2020;9(1): 78‑83

DOI: 10.17116/labs2020901178

Read: 1816 times

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Table of contents

CAN URINE LIPOCALIN-2 BE A MARKER OF ACUTE KIDNEY INJURY IN CARDIAC SURGICAL PATIENTS WITH AN INITIALLY NORMAL GLOMERULAR FILTRATION RATE?
CAN URINE LIPOCALIN-2 BE A MARKER OF ACUTE KIDNEY INJURY IN CARDIAC SURGICAL PATIENTS WITH AN INITIALLY NORMAL GLOMERULAR FILTRATION RATE?

To cite this article:

Ptitsyna AI, Stuf IYu, Kurapeev IS, Kozlov AV. Can urine lipocalin-2 be a marker of acute kidney injury in cardiac surgical patients with an initially normal glomerular filtration rate? Laboratory Service. 2020;9(1):78‑83. (In Russ.)
https://doi.org/10.17116/labs2020901178

Подписка 2025 Лабораторная служба (Laboratory Service)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Urine lipocalin-2 is used as an early biomarker of acute kidney injury (AKI) after cardiac surgery. According to our data the level of urine lipocalin-2 after 2 hours of cardiac surgery really has a diagnostic informative value in patients with initial glomerular filtration rate (GFR) above 85 ml×min–1 only. In patients with GFR in the range of 50—85 ml×min–1 this marker is not informative for the detection of AKI.

Keywords:

cardiac surgery
acute kidney injury
lipocalin-2
glomerular filtration rate

Authors:

Ptitsyna A.I.

Department of Clinical Laboratory Diagnostics North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Stuf I.Yu.

Department of Clinical Laboratory Diagnostics North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

Kurapeev I.S.

Mechnikov North-Western State Medical University of Ministry of Health of the Russia, St. Petersburg, Russia

Kozlov A.V.

Kraevaia klinicheskaia bol'nitsa, Barnaul

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References:

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  2. KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Kidney International Supplements. 2012;2:1-138.
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  4. Schiffl H. Cell cycle arrest biomarkers for the early prediction of acute kidney injury — full of promise, but not a must — have for yet. J Renal Inj Prev. 2017;6(3):177-183. https://doi.org/10.15171/jrip.2017.34
  5. McIlroy DR, Wagener G, Lee HT. Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury after Cardiac Surgery: The Effect of Baseline Renal Function on Diagnostic Performance. Clin J Am Soc Nephrol. 2010;5(2):211-219.
  6. Zhou F, Luo Q, Wang L, Han L. Diagnostic value of neutrophil gelatinase-associated lipocalin for early diagnosis of cardiac surgery-associated acute kidney injury: a meta-analysis. Eur J Cardiothorac Surg. 2016;49:746-55.
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  9. Istomin TA. Kurapeev IS. Mihaleva YB. Suborov EV. Domanskaya IA. Vasilieva GN. Custodiol cardioplegia: which protocol to prefer? Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta. 2017;9(3):32-39. (In Russ.)
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  12. de Geus HRH, Ronco C, Haase M, Jacob L, Lewington A, Vincent J-L. The cardiac surgery-associated neutrophil gelatinase-associated lipocalin (CSA-NGAL) score: a potential tool to monitor acute tubular damage. J Thorac Cardiovasc Surg. 2016;151:1476-1481.
  13. Rakesh C. Arora, Rohit K. Singal. Is routine use of renal injury biomarkers in cardiac surgery patients putting the cart before the horse? The Journal of Thoracic and Cardiovascular Surgery. 2017;3:938-939.
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