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Klypa T.V.

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies

Shepelyuk A.N.

Clinical Hospital №119 of the Federal Medical-Biological Agency of Russia, Moscow, Russia

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Antonov I.O.

Federal Research Clinical Center, FMBA of Russia, Moscow, Russia

Krichevsky L.A.

Filatov City Clinical Hospital №15, Moscow, Russia

Risk factors of cognitive dysfunction after cardiac surgery

Authors:

Klypa T.V., Shepelyuk A.N., Eremenko A.A., Antonov I.O., Krichevsky L.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2017;10(1): 62‑70

DOI: 10.17116/kardio201710162-70

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RISK FACTORS OF COGNITIVE DYSFUNCTION AFTER CARDIAC SURGERY
RISK FACTORS OF COGNITIVE DYSFUNCTION AFTER CARDIAC SURGERY

To cite this article:

Klypa TV, Shepelyuk AN, Eremenko AA, Antonov IO, Krichevsky LA. Risk factors of cognitive dysfunction after cardiac surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2017;10(1):62‑70. (In Russ.)
https://doi.org/10.17116/kardio201710162-70

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Aim. To analyze risk factors for postoperative cognitive dysfunction in cardiac patients. Material and methods. A total of 22 patients (16 men and 6 women) aged 62±0.7 years were examined. Mean NYHA functional class was 3.4±0.3. CPB surgery was performed (CPB time — 90±1.6 minutes, myocardial ischemia time — 62±1.3 minutes). In 81.8% of patients coronary artery bypass grafting (CABG) of 3.2±0.2 arteries was made, heart valve replacement — in 4.6% and combined surgery in 13.6%. Results. We evaluated the significance of early encephalopathy that manifests at the stage of patient waking after surgery and requires additional sedation. Preoperative and intraoperative clinical and laboratory predictors of postoperative encephalopathy were determined. We proved deterioration of electroencephalographic parameters and the results of neurocognitive testing in patients with early encephalopathy. Perioperative dynamics of inflammatory cytokines and markers of neuronal damage was defined. Conclusion. S-100 protein is the most informative neuronal marker. Cerebral complications are associated with significantly increased S-100 level compared with uncomplicated patients.

Keywords:

postoperative cognitive dysfunction
EEG
testing
predictors
cardiac surgery

Authors:

Klypa T.V.

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies

Shepelyuk A.N.

Clinical Hospital №119 of the Federal Medical-Biological Agency of Russia, Moscow, Russia

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Antonov I.O.

Federal Research Clinical Center, FMBA of Russia, Moscow, Russia

Krichevsky L.A.

Filatov City Clinical Hospital №15, Moscow, Russia

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