An important role in ensuring the territorial «program of the state guarantees of rendering of free medical aid» in the Omsk region is given to the centralization of laboratory analysis. The purpose of centralization is to improve the quality and accessibility of health care and financial savings in the region. The article presents the experience of the Omsk region on centralization of research in the determination of glycated hemoglobin (HbA1c) to detect prediabetes and diabetes. Lit institutional arrangements. Blood samples received from 84 institutions of the Omsk region. Special attention is paid to the preanalytical phase. Implemented automation of the preanalytical phase. To determine the level of HbA1c use the method of high performance liquid chromatography, certified in accordance with NGSP reference values. Ensured quality control in the format of inter-laboratory comparisons. The results of screening for diabetes mellitus based on the determination of HbA1c in 237366 residents of the Omsk region on the analyzers D10 and Vatiant II Turbo. The results of the diagnostic studies among the adult population the level of HbA1c ≥6.0% of the installed 57.91% of cases, including men — of 63.36%, women have 55.97%. The results of screening HbA1c ≥6.0% of diagnosed in 24.4% of patients.