Concentration of procalcitonin in the blood serum and peritoneal exudate after operations in the abdominal cavity

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The composition of exudates can have its own diagnostic value. Aim — the purpose of the study was to evaluate the content of PCT in the blood serum and peritoneal exudate in different course of the early postoperative period in patients with acute surgical pathology of the abdominal cavity organs. Material and methods. The concentration of procalcitonin (PCT) in blood serum and abdominal exudate was studied in 111 patients with different postoperative course. The main group (n=51) consisted of patients with pyoinflammatory complications. The comparison group (n=60) included patients with a favorable course of the postoperative period. The concentration of PCT was determined by ELISA using the test system “Procalcitonin — EIA — BEST” (Vector-Best, Russia). Results. The content of PCT in the serum of the patients of the main group was 3.75 ng/ml (interquartile range: 1.90—6.32) and exceeded the values of the comparison group, 0.165 and 0.057—0.59 ng/ml, respectively (р<0.001). The concentration of PCT in the exudate was lower than in the blood serum: in the main group 1.42 times and in the comparison group 1.7 times and differed 27 times between the groups (р<0.001). The concentration of PCT in the exudate depended on the serum concentration of PCT, and not on the nature of the exudate. A close positive correlation was found between the content of PCT in blood serum and abdominal exudate (R= 0.91; p<0.001), described by the linear regression equation Y= 0.057+0.6398 X. Conclusions. The obtained data testify to the absence of local production of PCT in the abdominal cavity and its passive penetration from the blood serum into the exudate by the concentration gradient. The most important factor determining the concentration of PCT in the exudate is the content of PCT in the blood serum.

Keywords:

exudate

procalcitonin

postoperative complications

systemic inflammatory response syndrome

Authors:

Yu Sosnin D.

GBOU VPO «Permskij gosudarstvennyj meditsinskij universitet im. akad. E.A. Vagnera», Perm', Rossija

Zubareva N.A.

Kraevaia klinicheskaia bol'nitsa #1 im. S.V. Ochapovskogo, Krasnodar

Yu Nenasheva O.

GBOU VPO «Permskij gosudarstvennyj meditsinskij universitet im. akad. E.A. Vagnera», Perm', Rossija

Popova N.N.

Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation

List of references:

Schneider HG, Lam QT. Procalcitonin for the clinical laboratory: a review Pathology. 2007;39(4):383-390. https://doi.org/10.1080/00313020701444564
Gao Y, Yu KJ, Kang K, Liu HT, Zhang X, Huang R, Qu JD, Wang SC, Liu RJ, Wang HL. Procalcitionin as a diagnostic marker to distinguish upper and lower gastrointestinal perforation. World J Gastroenterol. 2017;23(24):4422-4427. https://doi.org/10.3748/wjg.v23.i24.4422
Nunez Lopez O, Cambiaso-Daniel J, Branski LK, Norbury WB, Herndon DN. Predicting and managing sepsis in burn patients: current perspectives. Ther Clin Risk Manag. 2017;13:1107-1117. https://doi.org/10.2147/TCRM.S119938
Albrich WC, Harbarth S, Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting. Care Med. 2015:41(10):1739-1751. https://doi.org/10.1007/s00134-015-3978-8
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:426-435. https://doi.org/10.1016/S1473-3099(12)70323-7
Meisner M. Pathobiochemistry and clinical use of procalcitonin. Clin Chim Acta. 2002;323(1-2):17-29. https://doi.org/10.1016/S0009-8981(02)00101-8
Meisner M. Biomarkers of sepsis: clinically useful? Curr Opin Crit Care. 2005;11(5):473-480. https://doi.org/10.1097/01.ccx.0000176694.92883.ce
Zubareva NA., Sosnin DYu. Laboratory diagnosis of urinary tract damage. Urologiya. 2013;5:21-23. (In Russ.)
Cakir E, Deniz O, Ozcan O, Tozkoparan E, Yaman H, Akgul EO, Bilgi C, Bilgic H, Ekiz K, Erbil MK. Pleural fluid and serum procalcitonin as diagnostic tools in tuberculous pleurisy. Clin Biochem. 2005;38(3):234-238. https://doi.org/10.1016/j.clinbiochem.2004.11.008
Lin MC, Chen YC, Wu JT, Ko YC, Wang CC. Diagnostic and prognostic values of pleural fluid procalcitonin in parapneumonic pleural effusions. Chest. 2009;136(1):205-211. https://doi.org/10.1378/chest.08-1134
Na MJ. Diagnostic Tools of Pleural Effusion. Tuberc Respir Dis (Seoul). 2014;76(5):199-210. https://doi.org/10.4046/trd.2014.76.5.199
Zou MX, Zhou RR, Wu WJ, Zhang NJ, Liu WE, Fan XG. The use of pleural fluid procalcitonin and C-reactive protein in the diagnosis of parapneumonic pleural effusions: a systemic review and metaanalysis. Am J Emerg Med. 2012;30(9):1907-1914. https://doi.org/10.1016/j.ajem.2012.04.004
Lee SH, Lee EJ, Min KN, Hur GY, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Lee SY. Procalcitonin as a diagnostic marker in differentiating parapneumonic effusion from tuberculous pleurisy or malignant effusion. Clin Biochem. 2013;46(15):1484-1488. https://doi.org/10.1016/j.clinbiochem.2013.03.018
Viallon A, Zeni F, Pouzet V, Lambert C, Quenet S, Aubert G, Guyomarch S, Tardy B, Bertrand JC. Serum and ascetic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-imflammatory cytokines. Intensive Care Med. 2000;26(8):1082-1088. https://doi.org/10.1007/s001340051321
Spahr L, Morad I, Hadengue A, Vadas L, Pugin J. Prorocalcitonin is not an accurate marker of spontaneous bacterial peritonitis in patients with cirrhosis. Hepatogastroenterology. 2001;48(38):502-525.
Lesinska M, Hartleb M, Gutkowski K, Novakowska-Duława E. Procalcitonin and macrophage inflammatory protein-1 beta (MIP-1b) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis. Adv Med Sci. 2014;59(1):52-56. https://doi.org/10.1016/j.advms.2013.07.006
Komen N, Slieker Ju, Willemsen P, Mannaerts G, Pattyn P, Karsten T, de Wilt H, van der Harst E, de Rijke YB, Murawska M, Jeekel J, Lange JF. Acute phase proteins in drain fluid: a new screening tool for colorectal anastomotic leakage? APPEAL-study: analysis of parameters predictive for evident anastomotic leakage APPEAL Study Group. Am J Surgery. 2014;208(3):317-323. https://doi.org/10.1016/j.amjsurg.2013.09.024
Zhu P, Liang Z, Fu J, Chen W, Wang Z, Jiang H, Cui L. Procalcitonin in abdominal exudate to predict prolonged postoperative ileus following colorectal carcinoma surgery. Int J Biol Markers. 2013;28(2):187-191. https://doi.org/10.5301/jbm.5000028
Chereshnev VA, Sosnin DYu, Zubareva NA, Nenasheva OYu, Aksenova VM, Artemchik SV. The concentration of procalcitonin in the blood and enteral discharge in patients in the early postoperative period. Klinicheskaya laboratornaya diagnostika. 2014;59(12):20-24. (In Russ.)
Doğan C, Bilaçeroğlu S, Çirak AK, Özsöz A, Özbek D. Parapnömonik plevral efüzyon tanısında plevral sıvı ve serum prokalsitonin düzeylerinin tanısal değeri. Tuberk Toraks. 2013;61(2):103-109.

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