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Lyang O.V.

Assotsiatsija spetsialistov i organizatsij laboratornoj sluzhby «Federatsija laboratornoj meditsiny», 127083 Moskva, ul. 8 Marta, 1, str.12

Chernichuk O.V.

AU «Jugorskij tsentr professional'noj patologii», Hanty-Mansijsk

Zhirova I.A.

RUDN University, Moscow, Russia

Kochetov A.G.

Tsentr kardiokhirurgii i tsentr urologii 3-go Tsentral'nogo voennogo klinicheskogo gospitalia im. A.A. Vishnevskogo MO RF, Moskovskaia oblast', Krasnogorsk

Significance of oxidized low density lipoproteins in prediction of ischemic stroke course

Authors:

Lyang O.V., Chernichuk O.V., Zhirova I.A., Kochetov A.G.

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Journal: Laboratory Service. 2018;7(1): 25‑29

DOI: 10.17116/labs20187125-29

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To cite this article:

Lyang OV, Chernichuk OV, Zhirova IA, Kochetov AG. Significance of oxidized low density lipoproteins in prediction of ischemic stroke course. Laboratory Service. 2018;7(1):25‑29. (In Russ.)
https://doi.org/10.17116/labs20187125-29

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Ischemic stroke is the most common brain disease in middle aged and elderly and is accompanied by a high rate of disability and death. One of the main etiological causes of ischemic stroke is atherosclerotic vascular disease, leading eventually to thrombosis or embolization. Critical role in the progression of atherosclerosis play an oxidized low-density lipoprotein (ox-LDL), which is one of the products of oxidative stress, and might negatively affect the course of ischemic stroke with subsequent of hemorrhagic transformation and lethal outcome. The aim of this study was to examine the relationship of the initial concentration of ox-LDL over ischemic stroke, including the development of hemorrhagic transformation and lethal outcome. Material and methods. The study included 64 patients in the acute period of cerebral ischemic stroke. Hemorrhagic transformation of the lesion was observed in 17 patients, death during hospital stay - in 21 patients. 32 patients had a unfavorable course of stroke, favorable course was observed in 30 patients, 2 patients had course without changes. Oxidized LDL was determined by ELISA. The control group consisted of 25 healthy volunteers. Results. The concentration of ox-LDL in patients with stroke was 953.7 (50% 81.6 Q-777.9) U/ml and differ significantly from the values of the control group: 46,15 (50% of 33.5 Q-59.1) U/ml (p<0.05). We have not found the relationship of the concentration of ox-LDL with the severity of the condition, the volume of the lesion, development of hemorrhagic transformation and lethal outcome. Statistically significant differences in the concentration of ox-LDL were found only between the total group of patients with AI and control group and between the control group and the group with unfavorable course. Conclusion. The results of the study showed that the concentration of ox-LDL in patients with ischemic stroke is not correlated with the volume of the lesion, severity of ischemic stroke, hemorrhagic transformation and lethal outcome, which requires a revision of the pathophysiological role of ox-LDL. The obtained results suggest that LDL have a stress-protective effect neutralizing the products of oxidative stress by interacting with them and making ox-LDL.

Keywords:

low density lipoprotein
oxidized low density lipoprotein
ischemic stroke

Authors:

Lyang O.V.

Assotsiatsija spetsialistov i organizatsij laboratornoj sluzhby «Federatsija laboratornoj meditsiny», 127083 Moskva, ul. 8 Marta, 1, str.12

Chernichuk O.V.

AU «Jugorskij tsentr professional'noj patologii», Hanty-Mansijsk

Zhirova I.A.

RUDN University, Moscow, Russia

Kochetov A.G.

Tsentr kardiokhirurgii i tsentr urologii 3-go Tsentral'nogo voennogo klinicheskogo gospitalia im. A.A. Vishnevskogo MO RF, Moskovskaia oblast', Krasnogorsk

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