The high prevalence of psoriasis and seborrheic dermatitis, diversity of clinical picture, complexity of differential diagnosis, subjective feelings in the form of painfulness and itching, limitations in the choice of therapy, reduced quality of life and different prognoses determine the urgency of the problem. A large number of both external and internal factors leading to the onset of skin process, chronicity and tendency to recurrences requires careful analysis of lifestyle, diet, abuse of substances, heredity, features of the medical history and drug intake in each case with subsequent development of a diagnosis and treatment plan considering the comorbidities. The effectiveness of topical treatment in exacerbation of the skin process and maintenance therapy schemes, treatment satisfaction, adherence to therapy, stigmatization of patients are a limited spectrum of challenges in the clinical practice of dermatovenereologist. The article presents up-to-date data on the etiology, pathogenesis, diagnosis and treatment of psoriasis and seborrheic dermatitis with examples of clinical observations of the combination glucocorticosteroid product use in the therapy of these diseases. A range of nosologies has been outlined, portraits of patients, for which the administration of a medicinal product consisting of a combination of betamethasone 0.05% and salicylic acid 3% is indicated, have been given. Experience of application demonstrates the safety, effectiveness of such medicinal product, fast anti-inflammatory and anti-itching effects, which has a positive impact on the quality of life of patients.