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Khataeva D.I.

The Russian National Research Medical University named after N.I. Pirogov

Demina O.M.

Pirogov Russian National Research Medical University (RNRMU)

Kostalevskaya A.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Current causes of isotretinoin ineffectiveness in acne therapy

Authors:

Khataeva D.I., Demina O.M., Kostalevskaya A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2022;21(6): 819‑823

DOI: 10.17116/klinderma202221061819

Read: 6580 times

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Table of contents

CURRENT CAUSES OF ISOTRETINOIN INEFFECTIVENESS IN ACNE THERAPY
CURRENT CAUSES OF ISOTRETINOIN INEFFECTIVENESS IN ACNE THERAPY

To cite this article:

Khataeva DI, Demina OM, Kostalevskaya AV. Current causes of isotretinoin ineffectiveness in acne therapy. Russian Journal of Clinical Dermatology and Venereology. 2022;21(6):819‑823. (In Russ.)
https://doi.org/10.17116/klinderma202221061819

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Acne is a disease characterized by excessive sebum production, follicular hyperkeratosis, growth of Cutibacterium acnes, and inflammation. The systemic retinoid isotretinoin (13-cis-retinoic acid) intended for treating nodular-cystic acne has become the drug of choice for treating moderate to severe acne and is widely used in clinical practice. Particular attention is paid to studies for developing optimal regimens for this drug. However, in some cases, patients are unresponsive or develop acne recurrences after the first treatment course. Risk factors for recurrent acne after isotretinoin therapy may include severe disease, male gender, inadequate cumulative dose or duration of therapy, young age of patients, and family history of acne. An important way to improve treatment efficacy and identify patients with resistant acne is to detail the probable causes of isotretinoin failure to personalize and refine the therapeutic regimen.

Keywords:

acne
isotretinoin
causes of treatment failure
recurrences

Authors:

Khataeva D.I.

The Russian National Research Medical University named after N.I. Pirogov

Demina O.M.

Pirogov Russian National Research Medical University (RNRMU)

Kostalevskaya A.V.

Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology

Received:

26.03.2022

Accepted:

04.10.2022

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References:

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