Alopecia is one of the most common (17—34%) post-COVID symptoms while there is no consensus in the literature about the mechanism of hair loss associated with COVID-19. The presented clinical case of face and scalp skin lesions demonstrates the activation of various pathogenesis mechanisms of diffuse alopecia in a new coronavirus infection. COVID-19-associated manifestations of scalp vasculitis and seborrheic dermatitis that persisted for more than 12 weeks resulted in hair loss. The non-androgenic nature of alopecia was confirmed by trichodermoscopy. A uniform significant decrease in the hair density and average diameter (in the parietal and occipital regions), a large number of dysplastic hair that is typical diffuse non-androgenic alopecia was revealed. The treatment was carried out in several stages; a cream with betamethasone dipropionate, clotrimazole and gentamicin sulfate was used to stop exfoliation in the foci. The pathological skin process was resolved within 2 weeks of using the combined three-component cream. Restoration of hair growth took 3 months and included complex vitamin therapy and external application of naphthalan shampoo with herbal ingredients. The article is of interest to dermatovenerologists and specialists dealing with the problems of rehabilitation of patients with post-COVID symptoms.