Congenital epidermolysis bullosa is considered as a genetically and phenotypically heterogeneous group of diseases. Its main clinical manifestation is the formation of blisters on the skin and mucous membranes due to their trauma. Currently, the following clinical forms of congenital epidermolysis bullosa are distinguished: simple bullous, borderline bullous, dystrophic bullous and Kindler’s syndrome. Various forms of epidermolysis bullosa have genetic heterogeneity in the types of inheritance. When diagnosing epidermolysis bullosa, it is necessary to take into account such signs as onychodystrophy, hyperkeratosis of the palms and soles, hypo- and depigmentation of the skin, anemia. With a severe course of epidermolysis bullosa, contractures, pseudosyndactyly and anonychia can join. Some symptoms (alopecia, adentia, ankyloglossia, constipation, etc.) can be quite rare but they should also be taken into account when diagnosing this genodermatosis. Manifestations of epidermolysis bullosa can be observed immediately after birth and at a later date, and the latter include cicatricial atrophy, milia, contractures and pseudosyndactyly. For 2017—2020 on the territory of the republic, 256 patients with various forms of epidermolysis bullosa were identified, included in the National Register. A thorough analysis of clinical manifestations made it possible to identify the following forms of epidermolysis bullosa: simple — 126 (49.2%) patients, borderline — 18 (7.1%). dystrophic — 110 (42.9%) and Kindler’s syndrome — 2 (0.8%). 221 (86.3%) of 256 patients with epidermolysis bullosa had significant subjective sensations (itching, soreness). The analysis of the National Register of Epidermolysis Bullosa Patients showed that not in all cases the clinical picture of dermatosis makes it possible to establish the final diagnosis, especially in patients of the first year of life. Only histological and immunohistochemical studies can clarify the form of epidermolysis bullosa and outline the ways of drug correction.