For centuries the sportsmen have sought to improve their functional and strength performance through the use of various supplements in their food. Today the nutritional supplements are included in the diet of not only professional athletes but also amateurs working in fitness clubs and gyms. In pursuit of a sculpted body and an increase in strength capabilities amateur sportsmen take not only various dietary supplements and foods with high protein content but also anabolic androgenic steroids (AAS). Often at AAS the acne can occur and rapidly progress. This side effect of taking AAS has been known for a long time. But as recent foreign studies show the enzymes from whey protein extract which is used in high-protein foods for sportsmen may also be associated with the pathogenesis of acne. In our practice we have observed patients with moderate to severe acne actively involved in sports and eating foods high in protein. The management of these patients has its own characteristics. In the early stages of therapy with systemic retinoids the patients should significantly reduce physical activity. In addition it is necessary to choose a moisturizer that will help minimize the dehydrating effect of isotretinoin, normalize nutrition and fluid intake. Adequate selection of drugs and care products and correction of eating behavior taking into account the patient’s lifestyle can increase the patient’s compliance with the treatment.