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Khismatullina Z.R.

Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia, 450000

Amineva A.M.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Kurochkin D.P.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Gareeva D.F.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Zagidullin N.S.

Bashkir State Medical University, Russian Ministry of Health, Ufa, Russia

Psoriasis, psoriatic arthritis, metabolic disorders and cardiovascular disease. What is common?

Authors:

Khismatullina Z.R., Amineva A.M., Kurochkin D.P., Gareeva D.F., Zagidullin N.S.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(2): 139‑147

DOI: 10.17116/klinderma202019021139

Read: 11827 times

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Table of contents

PSORIASIS, PSORIATIC ARTHRITIS, METABOLIC DISORDERS AND CARDIOVASCULAR DISEASE. WHAT IS COMMON?
PSORIASIS, PSORIATIC ARTHRITIS, METABOLIC DISORDERS AND CARDIOVASCULAR DISEASE. WHAT IS COMMON?

To cite this article:

Khismatullina ZR, Amineva AM, Kurochkin DP, Gareeva DF, Zagidullin NS. Psoriasis, psoriatic arthritis, metabolic disorders and cardiovascular disease. What is common? Russian Journal of Clinical Dermatology and Venereology. 2020;19(2):139‑147. (In Russ.)
https://doi.org/10.17116/klinderma202019021139

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
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Abstract:

Psoriasis is a chronic immuno-inflammatory skin disease characterized by impaired proliferation and differentiation of epidermal keratinocytes involving both innate and adaptive immunity. The prevalence of psoriasis in the population is 1—4%. Recently, in connection with new data on the pathogenesis of the disease and the emergence of modern methods of treatment, such as biological therapy, it is important to have an idea of concomitant diseases, in particular cardiovascular. The literature review presents current data on the frequency of comorbidity of psoriasis, psoriatic arthritis with cardiovascular diseases and risk factors (coronary heart disease, diabetes mellitus, metabolic syndrome, obesity, arterial hypertension and dyslipidemia) and the general pathogenesis of these conditions. Discussed the results of meta-analyzes of randomized clinical trials on the association of psoriasis with cardiovascular diseases, in particular with the prevalence and severity of coronary atherosclerosis. Marked the pathogenetic role of interleukin-17 in the formation of these diseases and the effectiveness of modern biological therapy for treating not only psoriasis and psoriatic arthritis, but also metabolic disorders and cardiovascular diseases. Identified the future possibilities of biological therapy in reducing cardiovascular inflammation.

Keywords:

psoriasis
psoriatic arthritis
metabolic disorders
cardiovascular disease
comorbidity

Authors:

Khismatullina Z.R.

Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia, 450000

Amineva A.M.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Kurochkin D.P.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Gareeva D.F.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Zagidullin N.S.

Bashkir State Medical University, Russian Ministry of Health, Ufa, Russia

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