Modern non-invasive methods of diagnosis of melanocytic neoplasms of the facial skin

Garanina O.E.; Elagin V.V.; Davydova D.A.; Shlivko I.L.; Klemenova I.A.; Gubarkova E.V.; Orlinskaia N.Iu.; Zagainova E.V.

doi:https://doi.org/10.17116/klinderma201918051608

Garanina O.E.

Nizhny Novgorod State Medical Academy of the Ministry of Public Health of the Russia, Nizhny Novgorod, Russia, 603950

Elagin V.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

SPIN RSCI: 3539-8728
Scopus AuthorID: 16515845600
ResearcherID: Q-7095-2017
ORCID: 0000-0003-2676-5661

Davydova D.A.

Federal State Budgetary Institution «Privolzhsky Federal Research Medical Centre» of the Ministry of Health of the Russi, Nizhny Novgorod, Russia;
State Educational Establishment of Higher Professional Training Nizhny Novgorod State Medical Academy of the Ministry of Public Health of the Russia, Nizhny Novgorod, Russia

SPIN RSCI: 7263-7878
ORCID: 0000-0003-1030-190X

Shlivko I.L.

Nizhny Novgorod State Medical Academy, Nizhny Novgorod

Klemenova I.A.

Volga Federal Medical Research Center, Health Ministry of Russia, Nizhny Novgorod, Russia

Gubarkova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

Orlinskaia N.Iu.

Gorodskaia klinicheskaia bol'nitsa #12, Nizhniĭ Novgorod;
bol'nitsa skoroĭ meditsinskoĭ pomoshchi, Dzerzhinsk

Zagainova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

Modern non-invasive methods of diagnosis of melanocytic neoplasms of the facial skin

Authors:

Garanina O.E., Elagin V.V., Davydova D.A., Shlivko I.L., Klemenova I.A., Gubarkova E.V., Orlinskaia N.Iu., Zagainova E.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2019;18(5): 608‑615

DOI: 10.17116/klinderma201918051608

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To cite this article:

Garanina OE, Elagin VV, Davydova DA, et al. . Modern non-invasive methods of diagnosis of melanocytic neoplasms of the facial skin. Russian Journal of Clinical Dermatology and Venereology. 2019;18(5):608‑615. (In Russ.)
https://doi.org/10.17116/klinderma201918051608

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

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Abstract:

Melanoma incidence increases each year. It is one of the most aggressive skin tumors. Widely available dermatoscopy makes it possible to diagnose neoplasms with high diagnostic accuracy, especially in cases of facial localization, which are belong to the «gray» zone. Differential diagnosis of such neoplasms requires additional diagnostic methods, such as multiphoton tomography and optical coherence tomography angiography. In this study, benign and malignant melanocytic neoplasms of the facial skin with dermatoscopy index from 4.75 to 5.45 were researched. Based on the received results, it is demonstrated, that finding of one or more signs of malignant neoplasms (according to multiphoton tomography and optical coherence tomography angiography) is the factor of choice of aggressive surgical strategy.

Keywords:

melanocytic neoplasms of facial skin

melanoma in situ

invasive forms of melanoma

dermatoscopy

multiphoton tomography

optical coherence tomography angiography

Authors:

Garanina O.E.

Nizhny Novgorod State Medical Academy of the Ministry of Public Health of the Russia, Nizhny Novgorod, Russia, 603950

Elagin V.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

SPIN RSCI: 3539-8728
Scopus AuthorID: 16515845600
ResearcherID: Q-7095-2017
ORCID: 0000-0003-2676-5661

Davydova D.A.

SPIN RSCI: 7263-7878
ORCID: 0000-0003-1030-190X

Shlivko I.L.

Nizhny Novgorod State Medical Academy, Nizhny Novgorod

Klemenova I.A.

Volga Federal Medical Research Center, Health Ministry of Russia, Nizhny Novgorod, Russia

Gubarkova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

Orlinskaia N.Iu.

Gorodskaia klinicheskaia bol'nitsa #12, Nizhniĭ Novgorod;
bol'nitsa skoroĭ meditsinskoĭ pomoshchi, Dzerzhinsk

Zagainova E.V.

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia

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References:

Okhovat JP, Beaulieu D, Tsao H, et al. The first 30 years of the American Academy of Dermatology skin cancer screening program: 1985-2014. J Am Acad Dermatol. Nov, 2018;79(5):884-891.e3. https://doi.org/10.1016/j.jaad.2018.05.1242
Cutaneous melanoma. NCCN Clinical Practice Guidelines in Oncology. Version 2.2019 — March 12, 2019. Available at: https://www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdf
Mandala M, Massi D. Tissue prognostic biomarkers in primary cutaneous melanoma. Virchows Arch. Mar, 2014;464(3):265-81. https://doi.org/10.1007/s00428-013-1526-x
Weber P, Tschandl P, Sinz C, Kittler H. Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions. Curr Treat Options Oncol. Sep 20, 2018;19(11):56. https://doi.org/10.1007/s11864-018-0573-6
Dinnes J, Deeks JJ, Chuchu N, et al. Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults. Cochrane Database Syst Rev. Dec 4, 2018;12:CD011902. https://doi.org/10.1002/14651858.CD011902.pub2
Yelamos O, Braun RP, Liopyris K, et al. Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers. J Am Acad Dermatol. Feb, 2019;80(2):365-377. https://doi.org/10.1016/j.jaad.2018.07.072
Kittler H, Guitera P, Riedl E, et al. Identification of clinically featureless incipient melanoma using sequential dermoscopy imaging. Arch Dermatol. Sep, 2006;142(9):1113-1119. https://doi.org/10.1001/archderm.142.9.1113
Koenig K, Riemann I. High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution. J Biomed Opt. Jul, 2003;8(3):432-439.
Balu M, Zachary CB, Harris RM, et al. In Vivo Multiphoton Microscopy of Basal Cell Carcinoma. JAMA Dermatol. Oct, 2015;151(10):1068-1074. https://doi.org/10.1001/jamadermatol.2015.0453
Klemp M, Meinke MC, Weinigel M, et al. Comparison of morphologic criteria for actinic keratosis and squamous cell carcinoma using in vivo multiphoton tomography. Exp Dermatol. 25(3):218-222. https://doi.org/10.1111/exd.12912
Dimitrow E, Riemann I, Ehlers A, et al. Spectral fluorescence lifetime detection and selective melanin imaging by multiphoton laser tomography for melanoma diagnosis. Exp Dermatol. Jun, 2009;18(6):509-515. https://doi.org/10.1111/j.1600-0625.2008.00815.x
Koehler MJ, Preller A, Elsner P, et al. Non-invasive evaluation of dermal elastosis by in vivo multiphoton tomography with autofluorescence lifetime measurements. Exp Dermatol. Jan, 2012;21(1):48-51. https://doi.org/10.1111/j.1600-0625.2011.01405.x
Balu M, Kelly KM, Zachary CB, et al. Distinguishing between benign and malignant melanocytic nevi by in vivo multiphoton microscopy. Cancer Res. May, 2014;15,74(10):2688-2697. https://doi.org/10.1158/0008-5472.CAN-13-2582
Matveev LA, Zaitsev VY, Gelikonov GV, et al. Hybrid M-mode-like OCT imaging of three-dimensional microvasculature in vivo using reference-free processing of complex valued B-scans. Opt Lett. Apr, 2015;1,40(7):1472-1475. https://doi.org/10.1364/OL.40.001472
Sigsgaard V, Themstrup L, Theut Riis P, et al. In vivo measurements of blood vessels’ distribution in non-melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure? Skin Res Technol. Feb, 2018;24(1):123-128. https://doi.org/10.1111/srt.12399
Klinicheskie rekomendacii. Pravila provedeniya patologo-anatomicheskih issledovanij pri novoobrazovaniyah kozhi. Pod red. SHelekhovoj KV. Rossijskoe obshchestvo patologoanatomov. M., 2018. 2019:7. (In Russ.)
Skvara H, Teban L, Fiebiger M, et al. Limitations of Dermoscopy in the Recognition of Melanoma. Arch Dermatol. 2005;141(2):155-160.
Seidenari S, Arginelli F, Dunsby C, et al. Multiphoton laser tomography and fluorescence lifetime imaging of melanoma: morphologic features and quantitative data for sensitive and specific non-invasive diagnostics. PLoS One. 2013;8(7):e70682. https://doi.org/10.1371/journal.pone.0070682
Dimitrow E, Ziemer M, Koehler MJ, et al. Sensitivity and Specificity of Multiphoton Laser Tomography for In Vivo and Ex Vivo Diagnosis of Malignant Melanoma. J Invest Dermatol. Jul, 2009;129(7):1752-1758. https://doi.org/10.1038/jid.2008.439
Ribatti D, Annese T, Longo V. Angiogenesis and melanoma. Cancers (Basel). Feb, 2010;25,2(1):114-32. https://doi.org/10.3390/cancers2010114
Straume O, Salvesen HB, Akslen LA. Angiogenesis is prognostically important in vertical growth phase melanomas. Int J Oncol. 1999;15(3):595-599.
Schuh S, Holmes J, Ulrich M, et al. «Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology». Dermatol Ther (Heidelb). Jun, 2017;7(2):187-202. https://doi.org/10.1007/s13555-017-0175-4
De Carvalho N, Ciardo S, Cesinaro AM, et al. In vivo micro-angiography by means of speckle-variance optical coherence tomography (SV-OCT) is able to detect microscopic vascular changes in naevus to melanoma transition. J Eur Acad Dermatol Venereol. Oct, 2016;30(10):e67-e68. https://doi.org/10.1111/jdv.13311