Atopic dermatitis (AD) is one of the most common skin diseases. More than half of the cases originate in infancy, and subsequently assume a chronic recurrent course. This multifactorial dermatitis presents as the result of various provoking factors. An important place among them is occupied by infections, in particular, by contaminant bacteria, fungi and viruses. Treatment of these complicated atopic skin lesions is a complex task and requires an integrated approach. Among the various clinical manifestations of AD, the erythrodermic form is rare and rather severe, especially with a secondary infectious complication. In this instance, additional diagnostic difficulties arise, in particular, the ruling out of Kaposi-Juliusberg eczema herpeticum associated with the herpes simplex virus. Characteristics of this viral complication are disseminated vesicular, pustular and erosive rashes, and swollen cover with umbilicated lesions in the center of the elements. Fever up to 38 °C persists for 3—5 days. In the presented clinical observation, of an adolescent with an erythrodermic form of atopic dermatitis complicated by microbial infection, the exacerbation was arrested with minimally complex therapy, including prednisolone, cephazolin, reamberin and other means.