The interaction of atopic dermatitis with non-allergic diseases (in Russian only)

Varlamov E.E.; Pampura A.N.

doi:https://doi.org/10.17116/klinderma201918031345

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Abstract:

Atopic dermatitis (AtD) is a chronic inflammatory disease, the pathogenesis of which is based on the characteristics of the immune response and violation of the barrier properties of the skin. Symptoms of AtD are noted in 20% of children, half of them develop the disease within 1st year of life, and 95% — till 5 years of life. AtD is one of the earliest chronic inflammatory diseases in humans. At the same time, AtD is considered as the first stage of the development of an allergic march — a chronological sequence of the formation of sensitization and clinical manifestations of an allergy (AtD, bronchial asthma, allergic rhinitis). Recently, there is an increasing evidence of the interaction between allergic and non-allergic diseases. The pathogenesis of AtD goes beyond the scope of exclusively allergic pathology, and the concomitant immunological changes can not be interpreted as the exclusive dominance of Th2-immune response, which is peculiar to allergic rhinitis and bronchial asthma. The altered innate and adaptive immune response in patients with AtD induces the formation of inadequate response to various stimuli, which can be realized in the development of certain chronic inflammatory diseases. It is important to consider the possible impact of pharmacotherapy on the likelihood of developing comorbid diseases. In this regard, special attention should be paid to patients with severe AtD, receiving systemic and massive topical pharmacotherapy. This review presents data on the relationship of AtD with various non-allergic diseases: cardiovascular, oncological, metabolic diseases, systemic diseases of connective tissue, hematological, neurological, ophthalmological disorders, diseases of the gastrointestinal tract and non-allergic skin pathology.

Keywords:

atopic dermatitis

allergic march

non-allergic diseases

Authors:

Varlamov E.E.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ institut pediatrii i detskoĭ khirurgii" Minzdrava Rossii

Pampura A.N.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ institut pediatrii i detskoĭ khirurgii" Minzdrava Rossii

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