ABSTRACT Objective — the study was aimed at determining patient’s profile to select the advantageous topical formulation of adapalene and studying the efficacy and safety of the product used as a monotherapy and in combination with additional specialized cosmetics in treatment of mild to moderate acne. Material and methods. The study included 40 male and female patients aged 12 to 25 years with mild to moderate acne, who were divided into two groups of 20 patients (depending on skin type: oily or normal/combination, irritated, or sensitive). Each group was divided into two subgroups of 10 patients, depending on therapy. Results. Both dosage forms of adapalene (0.1% gel and cream) have high therapeutic efficacy. Concomitant administration of specialized cosmetics provides the best tolerability of therapy. Conclusions. Adapalene (0.1% gel and cream) used both as monotherapy and in combination with cosmetics is an effective topical agent with good safety profile for specialized treatment in patients with mild to moderate acne. It is recommended to use gel dosage form to treat patients with oily skin and cream dosage form in patients with normal or combination irritated or sensitive skin. It is advisable to use cosmetics as a supplementary therapy, which significantly improves comfort and tolerability of treatment.