Congenital epidermolysis bullosa (hereinafter CEB) is a severe congenital disease. There is a large number of patients with this diagnosis in Moscow megapolis. At present, advanced studies all over the world are aimed at the development of gene, cell, and protein-replacement therapies for patients with CEB. However, CEB patients need daily care in the form of dermatics and dressings. Objective — the study was aimed at analyzing the prevalence of CEB and studying clinical characteristics of the various forms of CEB in Moscow. Material and methods. The study was based on the data from the Moscow Scientific and Practical Center for Dermatology and Cosmetology of the Moscow Healthcare Department collected in 2013—2017. Results. This study for the first time ever evaluated prevalence and incidence pattern of CEB in Moscow, including disability pattern in children and adults with various forms of CEB in Moscow. Conclusion. Despite the fact that CEB is considered an orphan disease, patients with this genodermatosis may consult any practicing specialist.