The dermatotropic effects of naphthalan oil are well known and used in clinical practice, but not all of them are experimentally studied. For example, the literature lacks data on the effects of naphthalan on the sebaceous glands in experimental animals. Aim. To study experimentally the histological structure of the sebaceous glands upon cutaneous applications of a Naftaderm (liniment containing 10% naphthalan oil). This is applied research presented as a short communication. Material and methods. Naftaderm was applied to the interscapular area of male mice once a day for 2 weeks. The skin from the application area was studied morphometrically in histological sections stained with hematoxylin and eosin. The skin of unaffected animals was used as a control. Results. Compared to the control, the sebaceous glands in the skin of experimental mice were present not in all fields of vision, and their secretory compartments were reduced. According to morphometric studies, the medication containing naphthalan oil statistically significantly reduced the number of acinar profiles of the sebaceous glands in the microscope field of vision and the area of acinar profiles compared to those in the control. Conclusion. Our findings indicate that the sebostatic effect is one of the manifestations of pharmacological dermatotropic activity of naphthalan oil.