Candidiasis balanoposthitis as an important problem of superficial skin mycoses

Sokolova T.V.; Maliarchuk A.P.

doi:https://doi.org/10.17116/klinderma201716233-43

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Abstract:

The results of a literature data analysis indicate importance of the candidiasis balanoposthitis (CBP) problem for health care. Yeast-like fungi Candida albicans are more pathogenic than all other species and cause about 90% of superficial and 50—70% of deep candidiasis cases. Concomitant bacterial infection enhances pathogenic properties of the fungi. Fungi of the Candida spp. genus cause 30—35% of infectious balanoposthitis cases. CBP should be treated by single-component topical medications with antimycotic, antibacterial, and anti-inflammatory properties. Sertaconazole (Zalain) is one of these medications. Its activity against many Candida species is higher than that of fluconazole, bifonazole, and terbinafine. Purpose. The article purpose is to analyze the rate of CBP detection in Russia based on the results of two multicenter studies (2009—2010 and 2012—2013) and evaluate the efficacy of treatment with a topical antimycotic sertaconazole (Zalain) and a versatile antiseptic povidone-iodine (Betadine). Material and methods. The occurrence of superficial skin candidiasis and mucous membrane candidiasis in Russia was investigated in two multicenter studies. The first and second studies involved 19 and 50 Russian regions, 42 and 97 medical institutions, and 61 and 174 doctors, respectively. The efficacy of CBP treatment with sertaconazole (Zalain) was evaluated in 34 patients. Results. We analyzed the literature on the problem of superficial skin candidiasis (SSC) in general and CBP in particular. We found that SSC diagnosed based on ICD-10 (first study) accounted for 12.1% of superficial skin mycoses, and when the diagnosis was made based on a national classification (A.M. Arievich and Z.G. Stepanishcheva, 1965), which allowed for the diversity of nosological forms of candidiasis (second study), this indicator almost doubled (to 22.4%). The percentage of CBP was 47.7%. In males with candidiasis of large folds, CBP was detected in 87.5% of cases. We demonstrated a high efficacy of treatment of various clinical CBP forms with a sertaconazole (Zalain) cream and a versatile antiseptic povidone-iodine (Betadine). Recovery of patients with uncomplicated CBP occurred within 6—10 days (mean, 8.8±2.4 days). In the case of ulcerative and complicated forms of CBP, the process resolved within 12—17 days (mean, 14.2±1.8 days). Conclusion. The literature data and our findings indicate the interdisciplinary significance of the CBP problem and a high therapeutic efficacy of the sertaconazole (Zalain) cream in the treatment of this disease.

Keywords:

candidiasis

balanoposthitis

sertaconazole (Zalain)

povidone-iodine (Betadine)

Authors:

Sokolova T.V.

State Institute of Advanced Medical Training, Russian Ministry of Defense

SPIN RSCI: 6402-9066
Scopus AuthorID: 57213089279
ORCID: 0000-0003-3573-0874

Maliarchuk A.P.

State Institute of Advanced Medical Training, Russian Ministry of Defense

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