Today, the problem of chronic prostatitis (CP) becomes increasingly important due to the fact that this disease often results in infertility. Objective. The study is aimed at creating the model for individual prediction of fertility disorders in CP patients based on the comprehensive analysis of indicators, reflecting the activity of inflammation, collagen formation, microcirculation and vascular endothelium state, degree of peroxidation of proteins and lipids, activity of antioxidant protection, hormonal level, and semen parameters. Material and methods. We studied semen parameters, interleukin-8 (IL-8) and lactoferrin (LF) level in the seminal plasma, the level of C-reactive protein (CRP), transforming growth factor β1, C-terminal telopeptide of type I collagen, carboxyterminal propeptide of type I procollagen in the blood serum, some parameters of microcirculation and vascular endothelium state, oxidative stress indicators, superoxide dismutase activity, and hormonal profile in 140 fertile and 140 infertile CP patients with and without underlying sexually transmitted infections (STIs). Results. We conducted a comprehensive study of the state of skin microcirculation, microvascular reactivity, vasoregulative function of microvascular endothelium, and C-type natriuretic peptide plasma level in infertile and fertile CP patients with underlying STIs. In this work, we also determined the diagnostic value of inflammatory markers (IL-8, LF in seminal plasma, serum CRP) in infertile and fertile CP patients. The effect of STIs on the severity of the systemic inflammatory activation was elucidated: both the presence of sexually transmitted infection itself and mixed infections. We studied the intensity of peroxide oxidation of proteins and blood lipids, activity of antioxidant protection in infertile and fertile patients with chronic prostatitis, and evaluated the changes in these parameters depending on the presence of STIs. The important role of reduced sperm motility, STIs, and microcirculation disorders in the development of fertility disorders in patients with chronic prostatitis was shown. We have shown that reduced amount of spermatogenic cells, presence of pathological forms and dead sperm, increased PSA level, decreased antioxidant protection, hormonal changes (imbalance of luteinizing and follicle-stimulating hormone, estradiol, progesterone, prolactin, testosterone), as well as intensification of fibrogenesis processes in the prostate gland play an important role in the development of infertility. Conclusion. We developed a mathematical model for prediction of infertility in patients with CP, which takes into account the number of immobile spermatozoa, presence of STIs, and microcirculation effectiveness index. Implementation of the algorithm of individual infertility risk prediction in CP patients will enhance the quality of measures aimed at fertility normalization.