Objective: The objective of the study was to assess the association of rs1800795 polymorphism of IL6 gene, VNTR polymorphism in the intron 2 of IL1RN gene, and rs763780 polymorphism of IL17F gene with atopic dermatitis (AD) in the Russian population. Material and methods. A group of patients with AD (n = 100, 25% of males and 75 % of females). Control group consisted of two sub-groups. The first one included 100 individuals from the population sample of 25–35-year-old residents of the Oktyabrsky district of Novosibirsk and 100 secondary school students. Genomic DNA was isolated from the venous blood by phenol-chloroform extraction. Genotyping was performed using the polymerase chain reaction (VNTR, IL1RN gene) followed by analysis of restriction fragment length polymorphism (RFLP) (rs1800795 and rs763780). Results. The comparison of the groups under study in terms of the frequency of rs1800795 genotype of IL6 gene showed significant difference (p= 0.041). The odds ratio for CC genotype carriers getting into the group with AD is 1.7 times higher than for carriers of the other two genotypes (95% CI 1.1–2.9; p=0.028). However, when separating the results by gender, it was found that there are no significant differences between males with AD compared to the control group males. No significant differences between groups were detected in terms of the frequencies of VNTR genotypes and alleles of IL1RN gene and rs763780 of IL17F gene. Conclusion. rs1800795 polymorphism of IL6 gene is associated with AD. Carriage of CC genotype increases the risk of AD. Association of VNTR polymorphism of IL1RN gene and rs763780 polymorphism of IL17F gene with AD was not found.