The problem of syphilis in pregnancy is quite relevant because of the wave-like trend of the incidence rate of syphilis and the negative effect of this disease on pregnancy and the fetus. Objective. To determine the prevalence rate and epidemiological aspects of syphilis in pregnant women in the Republic of Belarus in 1996-2013, the number of cases and the main reasons for congenital syphilis (CS) in newborns, and the clinical features of syphilis in pregnant women and CS; to discuss the treatment and prevention strategy of CS. Material and methods. A retrospective analysis of the reports of dermatovenereological healthcare institutions in the Republic of Belarus, the data from out-patient medical records of patients who had syphilis in 1996-2013, and 127 congenital syphilis case investigation reports was carried out. Results. The problems associated with prevalence, clinical presentation, diagnosis, treatment, and prevention of CS and syphilis in pregnancy were discussed. The reasons for CS in newborns in the Republic of Belarus were analyzed. The clinical features of syphilis in pregnant women and CS were determined. The effectiveness of the strategy used to prevent and treat syphilis in pregnant women and CS in children in the Republic of Belarus. Conclusions. In 1996-2013, syphilis was diagnosed in 5017 pregnant women in the Republic of Belarus. Among the women who delivered babies with CS, 71.6% were not registered in dermatovenereological dispensaries; 77.2% of women were diagnosed with syphilis in a maternity hospital. In 1994-2013, CS was revealed in 127 newborns in the Republic of Belarus. Early CS is currently likely to be latent (81.1%); the detection rate of symptoms of cutaneous and mucosal lesions is much lower than the proportion of lesions affecting bones and internal organs. An effective system for prevention and treatment of syphilis in pregnancy and CS is used in the Republic of Belarus.