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Baĭtiakov V.V.

FGBOU VPO "Mordovskiĭ gosudarstvennyĭ universitet im. N.P. Ogareva"

Filimonkova N.N.

Ural Research Institute of Dermatovenerology and Immunopathology, Ekaterinburg

Clinical and immunological evaluation of the efficiency of extracorporeal blood correction in disseminated psoriasis

Authors:

Baĭtiakov V.V., Filimonkova N.N.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2012;10(4): 10‑15

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CLINICAL AND IMMUNOLOGICAL EVALUATION OF THE EFFICIENCY OF EXTRACORPOREAL BLOOD CORRECTION IN DISSEMINATED PSORIASIS
CLINICAL AND IMMUNOLOGICAL EVALUATION OF THE EFFICIENCY OF EXTRACORPOREAL BLOOD CORRECTION IN DISSEMINATED PSORIASIS

To cite this article:

Baĭtiakov VV, Filimonkova NN. Clinical and immunological evaluation of the efficiency of extracorporeal blood correction in disseminated psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2012;10(4):10‑15. (In Russ.)

 
Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)
 
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The effect of plasmapheresis and its modification with ozonation of returned red blood cell suspension on the course of the cutaneous process and on some immunological parameters was investigated in patients with disseminated psoriasis. Its clinical picture, the parameters of humoral immunity and a phagocytic process, and the serum levels of cytokines were studied over time. Patients with an exacerbation of disseminated psoriasis were observed to have elevated levels of tumor necrosis factor-α, interlekin-2, circulating immune complexes, immunoglobulins M and A, and enhanced neutrophil defense activity. There was a relationship between the study parameters to the clinical features of the disease, gender, age, and a family history.

Keywords:

psoriasis
cytokines
phagocytic process
immunoglobulins
immune complexes
plasmapheresis

Authors:

Baĭtiakov V.V.

FGBOU VPO "Mordovskiĭ gosudarstvennyĭ universitet im. N.P. Ogareva"

Filimonkova N.N.

Ural Research Institute of Dermatovenerology and Immunopathology, Ekaterinburg

List of references:

  1. Wahl A., Loge J.H., Wiklund I., Hanestad B.R. The burden of psoriasis: a study concerning health-related quality of life among Norwegian adult patients with psoriasis compared with general population norms. J Am Acad Dermatol 2000; 43: 5: 803-808.
  2. Kalinina N.M., Ketlinskii S.A., Okovityi S.V., Shulenin S.N. Zabolevaniya immunnoi sistemy. Diagnostika i farmakoterapiya. M: Eksmo 2008; 496.
  3. Katunina O.R. Rol' vrozhdennogo i adaptivnogo immuniteta v patogeneze psoriaza. Vestn dermatol i venerol 2009; 5: 43-48.
  4. Lepakhin V.K., Astakhova A.V., Ovchinnikova E.A., Ovchinnikova L.K. Vrachebnye oshibki kak prichina oslozhnenii lekarstvennoi terapii. Kachestv klin prakt 2002; 1: 71-77.
  5. Gutnikova A.R., Saidkhanov B.A., Azimova M.T., Kosnikova I.V. Effektivnost' raznykh metodik provedeniya plazmafereza pri lechenii rasprostranennykh dermatozov. Efferent ter 2010; 16: 4: 11-14.
  6. Pakirdinov A.B. Primenenie plazmafereza i giperbaricheskoi oksigenatsii v dermatologicheskoi praktike. Vestn dermatol i venerol 1998; 6: 35-36.
  7. Potekaev N.S., Kudrina M.I., Gorshkova N.N. i dr. Plazmaferez v terapii refrakternykh form psoriaza. Vestn dermatol i venerol 1990; 10: 35-37.
  8. Piksin I.N., Fedoseikin I.V., Byakin S.P. Kvantovye i efferentnye metody lecheniya v khirurgii. M: Nauka 2010; 248.
  9. Veksler N.Yu., Boyarinov G.A., Makarov N.A. i dr. Taktika intensivnoi terapii bol'nykh s ostrym destruktivnym pankreatitom. Vestn int terap 2004; 5: 180-183.
  10. Danilov A.Yu. Kliniko-patogeneticheskoe obosnovanie primeneniya efferentnykh metodov i ozonoterapii v rannei reabilitatsii bol'nykh, perenesshikh miomektomiyu: Avtoref. dis. … d-ra med. nauk. M 2009; 48.
  11. Maslennikov O.V., Kontorshchikova K.N., Gribkova I.A. Rukovodstvo po ozonoterapii. N. Novgorod: Vektor-TiS 2008; 326.
  12. Bel'tyukova A.S., Sysoev K.A., Khobeish M.M. i dr. Opredelenie urovnya 50 tsitokinov v syvorotke krovi bol'nykh psoriazom. Sovrem probl dermatoven immunol i vrachebn kosmetol 2011; 2: 15: 9-14.
  13. Kashperova O.G. Klinicheskaya effektivnost' i perenosimost' timodepressina v terapii detei s psoriazom. Klin dermatol i venerol 2009; 3: 41-45.
  14. Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today. J Biolog Regul Homeostat Agents 1997; 10: 2-3: 31-53.

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