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Fernando Diaz-Leon

Antenor Orrego Private University, Trujillo, Peru

José Caballero-Alvarado

Antenor Orrego Private University, Trujillo, Peru;
Regional Hospital of Trujillo, Trujillo, Peru

Carlos Zavaleta-Corvera

Antenor Orrego Private University, Trujillo, Peru

Víctor Lau-Torres

National University of Trujillo, Trujillo, Peru

Katherine Lozano-Peralta

Antenor Orrego Private University, Trujillo, Peru

Heart rate variability as a predictor of severity of acute appendicitis: a prospective analytical study

Authors:

Fernando Diaz-Leon, José Caballero-Alvarado, Carlos Zavaleta-Corvera, Víctor Lau-Torres, Katherine Lozano-Peralta

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2026;(3): 57‑62

DOI: 10.17116/hirurgia202603157

Read: 731 times

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Table of contents

HEART RATE VARIABILITY AS A PREDICTOR OF SEVERITY OF ACUTE APPENDICITIS: A PROSPECTIVE ANALYTICAL STUDY
HEART RATE VARIABILITY AS A PREDICTOR OF SEVERITY OF ACUTE APPENDICITIS: A PROSPECTIVE ANALYTICAL STUDY

To cite this article:

Fernando Diaz-Leon, José Caballero-Alvarado, Carlos Zavaleta-Corvera, Víctor Lau-Torres, Katherine Lozano-Peralta. Heart rate variability as a predictor of severity of acute appendicitis: a prospective analytical study. Pirogov Russian Journal of Surgery. 2026;(3):57‑62. (In Engl.)
https://doi.org/10.17116/hirurgia202603157

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate whether heart rate variability (HRV) is a predictive of severity of acute appendicitis.

MATERIAL AND METHODS

A cross-sectional and prospective study was conducted in 144 patients who underwent appendectomy. The sample included 111 patients with complicated appendicitis and 33 ones with uncomplicated appendicitis. Clinical data, HRV parameters and their predictive capacity for complicated appendicitis were evaluated. HRV was measured as the difference between minimum and maximum heart rate over three minutes before anesthetic induction. The student’s t-test and the ROC curve were used for statistical analysis.

RESULTS

Patients with complicated appendicitis had longer duration of illness (2.05±0.71 vs. 1.15±0.36 days, p=0.001) and higher leukocyte count (15.696.63±4.530.74 vs. 13.465.52±3.375.71, p=0.010). HRV was significantly lower in complicated cases (10.24±4.72 vs. 14.58±4.78, p=0.001). The area under the ROC curve was 0.750 (95% CI: 0.665—0.834) that indicated moderate predictive capacity of HRV for complicated appendicitis.

CONCLUSION

Heart rate variability was associated with severity of acute appendicitis, and HRV was lower in complicated cases. ROC curve suggests that HRV may be moderate predictor for identifying complicated appendicitis.

Keywords:

acute appendicitis
heart rate variability
prediction of severity
ROC curve
complicated appendicitis

Authors:

Fernando Diaz-Leon

Antenor Orrego Private University, Trujillo, Peru

José Caballero-Alvarado

Antenor Orrego Private University, Trujillo, Peru;
Regional Hospital of Trujillo, Trujillo, Peru

Carlos Zavaleta-Corvera

Antenor Orrego Private University, Trujillo, Peru

Víctor Lau-Torres

National University of Trujillo, Trujillo, Peru

Katherine Lozano-Peralta

Antenor Orrego Private University, Trujillo, Peru

Received:

21.01.2025

Accepted:

09.03.2025

Close metadata

References:

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