Radical cystectomy with fertility preservation for non-muscle invasive bladder cancer

Safiullin K.N.; Zaborskii I.N.; Ivanov S.A.; Kaprin A.D.

doi:https://doi.org/10.17116/onkolog20251402176

Safiullin K.N.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0002-3029-9213

Zaborskii I.N.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0001-5988-8268

Ivanov S.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

ORCID: 0000-0001-7689-6032

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Research Radiological Centre

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

Radical cystectomy with fertility preservation for non-muscle invasive bladder cancer

Authors:

Safiullin K.N., Zaborskii I.N., Ivanov S.A., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2025;14(2): 76‑82

DOI: 10.17116/onkolog20251402176

Read: 651 times

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To cite this article:

Safiullin KN, Zaborskii IN, Ivanov SA, Kaprin AD. Radical cystectomy with fertility preservation for non-muscle invasive bladder cancer. P.A. Herzen Journal of Oncology. 2025;14(2):76‑82. (In Russ.)
https://doi.org/10.17116/onkolog20251402176

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

Использование инфографики авторами научных работ

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Abstract:

Non-muscle invasive bladder cancer (NMIBC) includes stages Ta, T1 and CIS. Currently, NMIBC accounts for about 78% of newly diagnosed bladder cancer (BC). The main treatment method for NMIBC is transurethral resection of the bladder tumor (TUR) with early, single-dose adjuvant intravesical chemotherapy (CT). Subsequently, all patients are divided into prognostic factor risk groups. The main problem in treating patients is relapse of the disease; therefore, adjuvant therapy is recommended according to prognosis groups. In intermediate and high risk groups, relapse requires adjuvant intravesical therapy with maintenance courses. When prescribing the BCG vaccine, not all patients can complete the planned treatment due to adverse drug reactions, individual intolerance or refractoriness. In the EAU guidelines for NMIBC, the high-risk group has a subgroup of extremely high risk, in which radical cystectomy (RC) is indicated as the main treatment method. There are many publications on urine diversion and complications of surgical treatment. The question of performing RC with fertility preservation in patients with NMIBC remains relevant. This paper reviews previously published data on fertility preservation and oncological outcomes in patients included in the study. There are three main methods of fertility-preserving surgery: prostate-sparing, capsule-sparing and seminal vesicle-sparing cystectomy. The few studies on fertility preservation show heterogeneity in the groups of patients included in the study according to the stages of the disease and tumor grade. In this regard, ambiguous oncological results were obtained in the form of local relapse and progression. Perhaps, after determining the criteria for indications for RC in patients with NMIBC with preservation of fertility, the treatment method will be performed more widely in a certain group of patients.

Keywords:

non-muscle invasive bladder cancer

prognosis groups

survival

radical cystectomy

fertility

Authors:

Safiullin K.N.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0002-3029-9213

Zaborskii I.N.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre

ORCID: 0000-0001-5988-8268

Ivanov S.A.

A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre;
Peoples’ Friendship University of Russia named after Patrice Lumumba

ORCID: 0000-0001-7689-6032

Kaprin A.D.

Peoples’ Friendship University of Russia named after Patrice Lumumba;
National Medical Research Radiological Centre

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

Received:

27.09.2024

Accepted:

20.12.2024

Close metadata

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