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Vinnik Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Teplyakova O.V.

Voino-Yasenetsky Krasnoyarsk State Medical University

Erguleeva A.D.

Voino-Yasenetsky Krasnoyarsk State Medical University

Etiology and pathogenesis of infected pancreatic necrosis

Authors:

Vinnik Yu.S., Teplyakova O.V., Erguleeva A.D.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(8): 90‑97

DOI: 10.17116/hirurgia202208190

Read: 3613 times

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Table of contents

ETIOLOGY AND PATHOGENESIS OF INFECTED PANCREATIC NECROSIS
ETIOLOGY AND PATHOGENESIS OF INFECTED PANCREATIC NECROSIS

To cite this article:

Vinnik YuS, Teplyakova OV, Erguleeva AD. Etiology and pathogenesis of infected pancreatic necrosis. Pirogov Russian Journal of Surgery. 2022;(8):90‑97. (In Russ.)
https://doi.org/10.17116/hirurgia202208190

 
Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
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Abstract:

Modern literature data confirm the central role of intestinal barrier complex not only as a target in acute necrotizing pancreatitis, but also as a trigger for septic complications. Intra-abdominal hypertension, endothelial dysfunction and gut microbiome changes following necrotizing pancreatitis might have an independent impact on acute intestinal distress syndrome and bacterial translocation. Monitoring of these conditions and early target therapy can improve the outcomes in patients with severe acute pancreatitis. Adverse outcomes of infected pancreatic necrosis including high mortality and morbidity are largely due to the prevalence of multidrug-resistant bacterial pathogens.

Keywords:

acute pancreatitis
infected pancreatic necrosis
intra-abdominal hypertension
acute intestinal distress syndrome
endothelial dysfunction
microbiome
translocation
multidrug-resistant organisms

Authors:

Vinnik Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Teplyakova O.V.

Voino-Yasenetsky Krasnoyarsk State Medical University

Erguleeva A.D.

Voino-Yasenetsky Krasnoyarsk State Medical University

Received:

23.12.2021

Accepted:

11.01.2022

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