Complex treatment of lower limb ulcers in patients with diabetes mellitus type 2

Korovin A.Ya.; Popandopulo K.I.; Bazlov S.B.; Turkin D.V.

doi:https://doi.org/10.17116/hirurgia202204148

Korovin A.Ya.

Kuban State Medical University

Popandopulo K.I.

Kuban State Medical University

Bazlov S.B.

Kuban State Medical University

Turkin D.V.

Kuban State Medical University

Complex treatment of lower limb ulcers in patients with diabetes mellitus type 2

Authors:

Korovin A.Ya., Popandopulo K.I., Bazlov S.B., Turkin D.V.

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Journal: Pirogov Russian Journal of Surgery. 2022;(4): 48‑53

DOI: 10.17116/hirurgia202204148

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To cite this article:

Korovin AYa, Popandopulo KI, Bazlov SB, Turkin DV. Complex treatment of lower limb ulcers in patients with diabetes mellitus type 2. Pirogov Russian Journal of Surgery. 2022;(4):48‑53. (In Russ.)
https://doi.org/10.17116/hirurgia202204148

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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OBJECTIVE

To estimate the efficiency of stimulation of reparative processes in patients with diabetes mellitus type 2 and trophic ulcers of the lower limbs.

MATERIAL AND METHODS

There were 94 patients with diabetes mellitus type 2 complicated by trophic ulcers of the lower limbs. Mean age of patients was 67.8±8.6 years. The main group consisted of 50 (53.2%) patients who underwent stimulation of reparative processes, control group — 44 (46.8%) patients with standard treatment and hydrocolloid dressings. Efficiency of treatment was analyzed every 5 days considering wound healing and cytological data.

RESULTS

We found significant reduction of neurotrophic ulcer volume by 29.9% after 10 days. Positive macroscopic data were accompanied by reduction of white blood cells count up to 40-50% and increase in the number of histiocytes and endothelial cells. Among patients with ischemic ulcers, we obtained significant reduction of ulcerative defect only after 15-20 days in 3 (60%) cases. Overall efficiency of original management way 96%, mean duration of treatment — 37.1±5.9 days. In the control group, overall efficiency of treatment was 70.5%, duration of treatment — 45.9±6.1 days.

CONCLUSION

The original method was valuable to improve the outcomes in patients with diabetes mellitus type 2 and trophic ulcers of the lower limbs. The best results were obtained for neurotrophic ulcers. In case of ischemic ulcers, these technologies should be combined with measures on improvement of pulsatile blood flow and microcirculation. This method does not require hospitalization and reduces treatment cost.

Keywords:

diabetes mellitus

lower limb ulcers

platelet rich plasma

Authors:

Korovin A.Ya.

Kuban State Medical University

Popandopulo K.I.

Kuban State Medical University

Bazlov S.B.

Kuban State Medical University

Turkin D.V.

Kuban State Medical University

Received:

11.06.2021

Accepted:

12.07.2021

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References:

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