Meglumine sodium succinate for intensive therapy of diabetic ketoacidosis in school-aged children

Kozlov A.A.; Zavyalov A.E.; Emelyanov A.N.; Donskikh D.S.; Samsonov A.A.; Bedarev A.A.; Chuikova I.A.; Terentev D.A.

doi:https://doi.org/10.17116/anaesthesiology202506168

Kozlov A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0003-9121-031X

Zavyalov A.E.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0000-0002-4415-6344

Emelyanov A.N.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0007-2570-1742

Donskikh D.S.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0004-6794-0416

Samsonov A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0009-6706-7772

Bedarev A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0007-0639-1988

Chuikova I.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0008-9203-0130

Terentev D.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0004-9493-9357

Meglumine sodium succinate for intensive therapy of diabetic ketoacidosis in school-aged children

Authors:

Kozlov A.A., Zavyalov A.E., Emelyanov A.N., Donskikh D.S., Samsonov A.A., Bedarev A.A., Chuikova I.A., Terentev D.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(6): 68‑75

DOI: 10.17116/anaesthesiology202506168

Read: 417 times

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To cite this article:

Kozlov AA, Zavyalov AE, Emelyanov AN, et al. Meglumine sodium succinate for intensive therapy of diabetic ketoacidosis in school-aged children. Russian Journal of Anesthesiology and Reanimatology. 2025;(6):68‑75. (In Russ.)
https://doi.org/10.17116/anaesthesiology202506168

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the efficacy of 1.5% solution of meglumine sodium succinate (MSS) in children with moderate-to-severe DKA.

MATERIAL AND METHODS

An observational study included patients aged 7—17 years with moderate-to-severe DKA. All patients (n=60) received standard infusion therapy after admission to intensive care unit (ICU). Participants in the main group (n=30) additionally received 1.5% MSS at a dose of 10 ml/kg/day. Primary endpoints were time to DKA regression and proportion of patients with compensation after 24 and 48 hours. Logistic and linear regression methods were used.

RESULTS

DKA regressed in 90% of patients in the MSS group and 60% in the control group within 24 hours (p<0.001). After 48 hours, DKA regressed in all patients of both groups. In the main group, time to DKA regression was 16.5 hours, ICU-stay — 20.0 hours, time to recovery of consciousness — 4.0 hours. In the control group, these values were 24.0, 29.2 and 8.0 hours, respectively (p<0.001).

CONCLUSION

We observed superiority of MSS for infusion therapy in school-age children with moderate-to-severe DKA. Faster normalization of clinical and laboratory parameters in the MSS group reduced ICU-stay.

Keywords:

diabetes mellitus

diabetic ketoacidosis

crystalloid solution

infusion therapy

1.5% solution of meglumine sodium succinate (Reamberin)

Authors:

Kozlov A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0003-9121-031X

Zavyalov A.E.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0000-0002-4415-6344

Emelyanov A.N.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0007-2570-1742

Donskikh D.S.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0004-6794-0416

Samsonov A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0009-6706-7772

Bedarev A.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0007-0639-1988

Chuikova I.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0008-9203-0130

Terentev D.A.

Altai Regional Clinical Center for Maternal and Child Health

ORCID: 0009-0004-9493-9357

Received:

06.06.2025

Accepted:

27.08.2025

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References:

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