Collagen-based biological dressings in the treatment of chronic wounds in diabetic foot syndrome

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One of the end-organs of diabetes mellitus (DM) is the skin. Cellular and molecular disorders occurring in the skin due to chronic hyperglycemia, neuropathy, and micro- and macroangiopathy lead to poor-heling foot wounds in patients with diabetes. Consequently, treating wounds in diabetic foot syndrome (DFS) is prolonged, costly, and often ineffective. The research on wound healing and treating wounds in DM with stricter adherence to international guidelines and technological breakthroughs in developing biological materials provide new therapeutic opportunities to solve wound care problems. Collagen is one of the body’s many proteins, essential throughout the healing phases for skin repair and remodeling. Collagen is one of the body’s many proteins, essential throughout the healing phases for skin repair and remodeling. The article addresses the features of biological dressings based on the lyophilized native triple-helix (non-hydrolyzed) collagen formulation. Also, we present clinical cases of their use in different phases of wound healing in DM.

Keywords:

diabetes mellitus

diabetic foot syndrome

wound

phases of healing

non-hydrolyzed collagen

collagenases

hemostasis

inflammation

proliferation

remodeling

surgical treatment

Authors:

Maximova N.V.

Central Clinical Hospital with Outpatient Clinic of the Department of Presidential Affairs of the Russian Federation

Kovylov A.O.

Endocrinological Dispensary of the Moscow Health Department

Received:

10.09.2022

Accepted:

28.09.2022

List of references:

International Diabetes Federation. IDF Diabetes Atlas, 9th edn. Brussels; 2019.
Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, Cavan D, Shaw JE, Makaroff LE. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40-50. https://doi.org/10.1016/j.diabres.2017.03.024
Shestakova MV, Vikulova OK, Zheleznyakova AV, Isakov MA, Dedov II. Diabetes epidemiology in Russia: what has changed over the decade? Therapeutic Archive. 2019;91(10):4-13. (In Russ.). https://doi.org/10.26442/00403660.2019.10.000364;
Margolis DJ, Kantor J, Berlin JA. Healing of diabetic neuropathic foot ulcers receiving standard treatment. Diabetes Care. 1999;22(5):692-695. https://doi.org/10.2337/diacare.22.5.692
Udovichenko OV, Berseneva EA. Efficacy of routine diabetic foot treatments at an outpatient clinic: a cohort study. Diabetes mellitus. 2014;17(3):107-112. (In Russ.). https://doi.org/10.14341/DM20143107-112
Warriner RA, Snyder RJ, Cardinal MH. Differentiating diabetic foot ulcers that are unlikely to heal by 12 weeks following achieving 50% percent area reduction at 4 weeks. Int Wound J. 2011;8(6):632-637. https://doi.org/10.1111/j.1742-481X.2011.00860.x
International Working Group on the Diabetic Foot (IWGDF). Website. Accessed November 8. 2022. https://www.iwgdfguidelines.org
Privol’nev VV, Paskhalova YuS, Rodin AV, Mitish VA.Local treatment for wounds and wound infection according to the results of an anonymous survey of surgeons in Russia. Wounds and wound infection. Zhurnal im prof. B.M. Kostuchenkova. 2016;3(1):19-24. https://doi.org/10.17650/2408-9613-2016-3-1-19-24
Privol’nev VV. Optimization of antibiotic therapy for diabetic foot infections: Dis. ... kand. med. nauk. M. 2011.
Galstyan GR, Vikulova OK, Isakov MA, Zheleznyakova AV, Serkov AA, Egorova DN, Artemova EV, Shestakova MV, Dedov II. Trends in the epidemiology of diabetic foot and lower limb amputations in Russian Federation according to the Federal Diabetes Register (2013—2016). Diabetes mellitus. 2018;21(3):170-177. https://doi.org/10.14341/DM9688
Hemm RL. Rany. Diagnostika i lechenie: atlas-spravochnik. Per. s anglyu pod red. Mitisha V.A., Paskhalovoj Yu.S. M.: GEOTAR-Media; 2021.
Singer AJ, Clark RA. Cutaneus wound healing. N Engl J Med. 1999;341(10):738-746. https://doi.org/10.1056/NEJM199909023411006
Galstyan KO. The significance of metabolic and pro-inflammatory factors in the development of diabetic foot syndrome: Dis. ... kand. med. nauk. M. 2020.
Maksimova NV, Lyundup AV, Lubimov RO, Melnichenko GA, Nikolenko VN. Pathophysiological aspects of wound healing in normal and diabetic foot. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. 2014;11-12:110-117.
Tchaikovski V, Olieslagers S, Bohmer FD, Waltenberger J. Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes. Circulation. 2009;120(2):150-159. https://doi.org/10.1161/CIRCULATIONAHA.108.817528
Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interaction in wound healing. J Invest Dermatol. 2007;127(5):998-1008. https://doi.org/10.1038/sj.jid.5700786
Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736-1743. https://doi.org/10.1016/S0140-6736(05)67700-8
Loots MA, Lamme EN, Mekkes JR, Bos JD, Middelkoop E. Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation. Arch Dermatol Res. 1999;291(2-3):93-99. https://doi.org/10.1007/s004030050389
Liao H, Zakhaleva J, Chen W. Cells and tissue interactions with glycated collagen and their relevance to delayed diabetic wound healing. Biomaterials. 2009;30(9):1689-1696. https://doi.org/10.1016/j.biomaterials.2008.11.038
McCallon SK, Weir D, Lantis JC. Optimizing wound bed preparation with collagenase enzymatic debridement. The Journal of the American College of Clinical Wound Specialists. 2014;6(1-2):14-23. https://doi.org/10.1016/j.jccw.2015.08.003
Edmonds M, Foster A. The ulcerated foot. Managing the Diabetic Foot. London: Blakewell Science; 2000.
Glyantsev SP, Vishnevsky AV, Adamyan AA, Vishnevsky AV, Sakharov IYu. Crab collagenase in wound debridement. Journal of Wound Care. 1997;6(1):13-16. https://doi.org/10.12968/jowc.1997.6.1.13
Mayorova AV, Sysuev BB, Ivankova JO, Hanalieva IA. Collagenases in medical practice: modern collagenase-based preparations and prospects for their improvement. Pharmacy & Pharmacology. 2019;7(5):260-270. https://doi.org/10.19163/2307-9266-2019-7-5-260-270
Artyukov AA, Menzorova NI, Kozlovskaya EP, Kofanova NN, Kozlovsky AS, Rasskazov VA. Enzyme preparation from hepatopancreas of commercial crabs and method for its preparation: for the invention (RF). Patent 2280076 RF C12N9/48 C12N9/64 — No. 2004135771/13, Appl. 06.12.04.; publ. 07/20/2006. (In Russ.).
Isaev VA, Lyutova LV, Karabasova MA, Rudenskaya GN, Kupenko OG, Stepanov VM. Composition for the treatment of purulent-trophic ulcers and bedsores. Patent RF 2074709 A61K 9/06 — No. 925054708, Appl. 07/10/1992, publ. 03/10/1997. (In Russ.).
Kashtanov AD, Vasilyev YuL, Kuzin AN, Boronikhina TV, Chilikov VV. Experience in the use of non-contact thermometry in evaluating the effi cacy of treating small shallow wounds with trophic disorders of collagen-based sponge and dihestase. Operativnaya khirurgiya i klinicheskaya anatomiya (Pirogovskii nauchnyi zhurnal). 2019;3(4):21-27. (In Russ.). https://doi.org/10.17116/operhirurg2019304121
Report on the use of the biological dressing Digestol in the complex treatment of children with thermal injury in the children’s regional burn center based on the Lyubertsy Children’s City Hospital. (In Russ.).
Rangaraj A, Harding K, Leaper D. Role of collagen in wound management. Wounds UK. 2011;7(2):54-63.
Human BioSciences Kollagen Technology Rev.1/April 1996/Updated February 2021.
Fayzullin AL, Shekhter AB, Istranov LP, Istranova EV, Rudenko TG, Guller AE, Aboyants RK, Timashev PS, Butnaru DV. Bioresorbable collagen materials in surgery: 50 years of success. Sechenov Medical Journal. 2020;11(1):59-70. (In Russ.). https://doi.org/10.47093/2218-7332.2020.11.1.59-70

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