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Maximova N.V.

Central Clinical Hospital with Outpatient Clinic of the Department of Presidential Affairs of the Russian Federation

Kovylov A.O.

Endocrinological Dispensary of the Moscow Health Department

Collagen-based biological dressings in the treatment of chronic wounds in diabetic foot syndrome

Authors:

Maximova N.V., Kovylov A.O.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(12): 109‑116

DOI: 10.17116/hirurgia2022121109

Read: 5357 times

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Table of contents

COLLAGEN-BASED BIOLOGICAL DRESSINGS IN THE TREATMENT OF CHRONIC WOUNDS IN DIABETIC FOOT SYNDROME
COLLAGEN-BASED BIOLOGICAL DRESSINGS IN THE TREATMENT OF CHRONIC WOUNDS IN DIABETIC FOOT SYNDROME

To cite this article:

Maximova NV, Kovylov AO. Collagen-based biological dressings in the treatment of chronic wounds in diabetic foot syndrome. Pirogov Russian Journal of Surgery. 2022;(12):109‑116. (In Russ.)
https://doi.org/10.17116/hirurgia2022121109

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

One of the end-organs of diabetes mellitus (DM) is the skin. Cellular and molecular disorders occurring in the skin due to chronic hyperglycemia, neuropathy, and micro- and macroangiopathy lead to poor-heling foot wounds in patients with diabetes. Consequently, treating wounds in diabetic foot syndrome (DFS) is prolonged, costly, and often ineffective. The research on wound healing and treating wounds in DM with stricter adherence to international guidelines and technological breakthroughs in developing biological materials provide new therapeutic opportunities to solve wound care problems. Collagen is one of the body’s many proteins, essential throughout the healing phases for skin repair and remodeling. Collagen is one of the body’s many proteins, essential throughout the healing phases for skin repair and remodeling. The article addresses the features of biological dressings based on the lyophilized native triple-helix (non-hydrolyzed) collagen formulation. Also, we present clinical cases of their use in different phases of wound healing in DM.

Keywords:

diabetes mellitus
diabetic foot syndrome
wound
phases of healing
non-hydrolyzed collagen
collagenases
hemostasis
inflammation
proliferation
remodeling
surgical treatment

Authors:

Maximova N.V.

Central Clinical Hospital with Outpatient Clinic of the Department of Presidential Affairs of the Russian Federation

Kovylov A.O.

Endocrinological Dispensary of the Moscow Health Department

Received:

10.09.2022

Accepted:

28.09.2022

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References:

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