Surgical treatment of mega aorta syndrome: a single-center experience

Belov Yu.V.; Charchyan E.R.; Breshenkov D.G.; Akselrod B.A.; Eremenko A.A.; Markin A.V.; Panov A.V.; Goryagin A.O.; Nikonova T.A.

doi:https://doi.org/10.17116/hirurgia202106215

Belov Yu.V.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

SPIN RSCI: 2740-1439
Scopus AuthorID: 7101862336
ResearcherID: 7101862336
ORCID: 0000-0002-9280-8845

Charchyan E.R.

Petrovsky National Research Centre of Surgery

SPIN RSCI: 4641-0523
Scopus AuthorID: 14044681400
ORCID: 0000-0002-0488-2560

Breshenkov D.G.

Petrovsky National Research Centre of Surgery

Akselrod B.A.

Petrovsky National Research Center of Surgery

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

ORCID: 0000-0001-5809-8563

Markin A.V.

Petrovsky Russian Scientific Center of Surgery

Panov A.V.

Petrovsky Russian Research Center of Surgery

Goryagin A.O.

Petrovsky Russian Scientific Center of Surgery

Nikonova T.A.

Petrovsky Russian Scientific Center of Surgery

Surgical treatment of mega aorta syndrome: a single-center experience

Authors:

Belov Yu.V., Charchyan E.R., Breshenkov D.G., Akselrod B.A., Eremenko A.A., Markin A.V., Panov A.V., Goryagin A.O., Nikonova T.A.

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Journal: Pirogov Russian Journal of Surgery. 2021;(6‑2): 15‑25

DOI: 10.17116/hirurgia202106215

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To cite this article:

Belov YuV, Charchyan ER, Breshenkov DG, et al. . Surgical treatment of mega aorta syndrome: a single-center experience. Pirogov Russian Journal of Surgery. 2021;(6‑2):15‑25. (In Russ.)
https://doi.org/10.17116/hirurgia202106215

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To present our experience in the treatment of severe patients with mega aorta syndrome.

MATERIAL AND METHODS

There were 49 patients with mega aorta syndrome for the period from May 2015 to March 2021. All patients underwent total aortic replacement from sinotubular junction (with staged aortic root repair, if necessary) to abdominal aorta bifurcation. All surgeries were elective. All patients were divided into two groups: group I (n=33; 67.3%) — staged replacement, group II (n=16; 32.7%) — one-staged replacement of the aorta via thoracophrenolumbotomy. The primary endpoints were mortality, perioperative parameters and complications. We also analyzed long-term freedom from aortic redo surgery and survival rate.

RESULTS

Both groups were comparable by pre-, intra- and postoperative parameters. The interval between surgeries for staged approach was 7.1±2.3 months. Rehabilitation time considering two stages was longer in group I (13±2 vs. 5.5±1.1 months, p=0.0001). Between-stage mortality rate was 12% (n=4). Intraoperative mortality was absent in both groups. In-hospital mortality was 3% and 12% (p=0.25), overall mortality with between-stage interval — 10.2% and 12% (p=1.000), respectively. The follow-up period was similar (18±22.7 (range 1-71) and 23.3±19.1 (range 1-51) months, respectively (p=0.63)). In group I, 1-year, 3-year and 5-year survival rate considering between-stage mortality was 89% (95% CI 78-100%), 77.1% (95% CI 60.1-98.8%), 77.1% (95% CI 60.1-98.8%), respectively. In group II, 1-year and 3-year survival rate was 86.5% (95% CI 70.5-100%), p_log-rank=0.88. Overall freedom from redo surgery was 92.9% (95% CI 80.3-100%) vs. 90.9% (95% CI 75.4-100%), p_log-rank=0.072.

CONCLUSION

One-stage total aortic replacement via thoracophrenolumbotomy is safe surgical treatment for mega aorta syndrome, especially in young patients with low surgical risk. Favorable outcomes may be expected in specialized centers with extensive experience in aortic surgery. Compared to staged approach, total aortic replacement eliminates the risks of between-stage aortic rupture. Therefore, it is a worthy alternative to other methods.

Keywords:

mega aorta syndrome

aneurysm

total aortic replacement

staged approach

hybrid surgery

one-stage replacement

thoracophrenolumbotomy

Authors:

Belov Yu.V.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

SPIN RSCI: 2740-1439
Scopus AuthorID: 7101862336
ResearcherID: 7101862336
ORCID: 0000-0002-9280-8845

Charchyan E.R.

Petrovsky National Research Centre of Surgery

SPIN RSCI: 4641-0523
Scopus AuthorID: 14044681400
ORCID: 0000-0002-0488-2560

Breshenkov D.G.

Petrovsky National Research Centre of Surgery

Akselrod B.A.

Petrovsky National Research Center of Surgery

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

ORCID: 0000-0001-5809-8563

Markin A.V.

Petrovsky Russian Scientific Center of Surgery

Panov A.V.

Petrovsky Russian Research Center of Surgery

Goryagin A.O.

Petrovsky Russian Scientific Center of Surgery

Nikonova T.A.

Petrovsky Russian Scientific Center of Surgery

Received:

12.04.2021

Accepted:

28.04.2021

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