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Aslanidis I.P.

Bakulev Research Center for Cardiovascular Surgery

Pursanova D.M.

Bakulev Research Center for Cardiovascular Surgery

Mukhortova O.V.

Bakulev Research Center for Cardiovascular Surgery

Shurupova I.V.

Bakulev Research Center for Cardiovascular Surgery

Ekaeva I.V.

Bakulev Research Center for Cardiovascular Surgery

Arakelyan V.S.

Bakulev Research Center for Cardiovascular Surgery

Golukhova E.Z.

Bakulev National Medical Research Center for Cardiovascular Surgery

Mironenko V.A.

Bakulev National Medical Research Center of Cardiovascular Surgery

Garmanov S.V.

Bakulev National Medical Research Center of Cardiovascular Surgery

Popov D.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

18F-fluorodeoxyglucose PET/CT in the diagnosis of vascular graft infection

Authors:

Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Ekaeva I.V., Arakelyan V.S., Golukhova E.Z., Mironenko V.A., Garmanov S.V., Popov D.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2021;(2): 58‑66

DOI: 10.17116/hirurgia202102158

Views: 3697

Downloaded: 78

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Table of contents

To cite this article:

Aslanidis IP, Pursanova DM, Mukhortova OV, et al. . 18F-fluorodeoxyglucose PET/CT in the diagnosis of vascular graft infection. Pirogov Russian Journal of Surgery. 2021;(2):58‑66. (In Russ.)
https://doi.org/10.17116/hirurgia202102158

Подписка 2025 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

To investigate diagnostic role of 18F-fluorodeoxyglucose PET/CT in patients with suspected vascular graft (VG) infection.

MATERIAL AND METHODS

A prospective analysis included data of 30 PET/CT examinations for suspected infection of aortic VG (n=27) and bypass grafts (n=3) after surgical treatment (median 48 months). In 77% (23/30) of cases, the diagnosis was initially «possible» (n=11) or «rejected» (n=12) in accordance with common diagnostic criteria. All PET/CT results were verified by clinical, laboratory and intraoperative («=20) data. VG infection was confirmed in 18 patients and ruled out in 12 cases.

RESULTS

PET/CT confirmed VG infection in 94% (17/18) and excluded in 50% (6/12) of cases. False PET/CT results were obtained in 23% (7/30) cases: false positive in 6 cases and false negative in 1 case. Thus, sensitivity, specificity and diagnostic accuracy of PET/CT were 94%, 50% and 77%, respectively; positive and negative predictive value — 74% and 86%. PET/CT results allowed correct reclassifying 33% (10/30) of cases. VG infection was confirmed in 73% (8/11) of patients with initially «possible» diagnosis and excluded in 17% (2/12) of patients with initially «rejected» infection. Moreover, whole body PET/CT revealed unknown inflammation foci outside VG in 73% (22/30) of cases. These data were applied to correct treatment approach in 80% (24/30) of cases.

CONCLUSION

Our results showed high efficacy of 18F-fluorodeoxyglucose PET/CT in the diagnosis of VG infection. Despite low specificity, this technique has high sensitivity and accuracy that allowed reclassifying 33% of cases.

Keywords:

PET/CT
18F-FDG
18F-fluorodeoxyglucose
infection
vascular graft
prosthesis

Authors:

Aslanidis I.P.

Bakulev Research Center for Cardiovascular Surgery

Pursanova D.M.

Bakulev Research Center for Cardiovascular Surgery

Mukhortova O.V.

Bakulev Research Center for Cardiovascular Surgery

Shurupova I.V.

Bakulev Research Center for Cardiovascular Surgery

Ekaeva I.V.

Bakulev Research Center for Cardiovascular Surgery

Arakelyan V.S.

Bakulev Research Center for Cardiovascular Surgery

Golukhova E.Z.

Bakulev National Medical Research Center for Cardiovascular Surgery

Mironenko V.A.

Bakulev National Medical Research Center of Cardiovascular Surgery

Garmanov S.V.

Bakulev National Medical Research Center of Cardiovascular Surgery

Popov D.A.

Bakulev National Medical Research Center for Cardiovascular Surgery

Received:

16.10.2020

Accepted:

15.11.2020

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