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Kalinin R.E.

I.P. Pavlov Ryazan State Medical University, Ryazan

Suchkov I.A.

I.P. Pavlov Ryazan State Medical University, Ryazan

Mzhavanadze N.D.

Pavlov Ryazan State Medical University of Ministry of Health of Russia, Ryazan, Russia

Demikhov V.G.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

Zhurina O.N.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

Klimentova E.A.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

Hemostatic changes in patients with peripheral artery disease before and after bypass surgery

Authors:

Kalinin R.E., Suchkov I.A., Mzhavanadze N.D., Demikhov V.G., Zhurina O.N., Klimentova E.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2018;(8): 46‑49

DOI: 10.17116/hirurgia2018846

Read: 1114 times

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Table of contents

HEMOSTATIC CHANGES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE BEFORE AND AFTER BYPASS SURGERY
HEMOSTATIC CHANGES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE BEFORE AND AFTER BYPASS SURGERY

To cite this article:

Kalinin RE, Suchkov IA, Mzhavanadze ND, Demikhov VG, Zhurina ON, Klimentova EA. Hemostatic changes in patients with peripheral artery disease before and after bypass surgery. Pirogov Russian Journal of Surgery. 2018;(8):46‑49. (In Russ.)
https://doi.org/10.17116/hirurgia2018846

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
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Abstract:

Aim. To assess intrinsic coagulation pathway factors activity and hemostatic markers of endothelial dysfunction in patients with peripheral artery disease (PAD) before and after lower extremity bypass surgery. Material and methods. 80 patients with PAD Fontaine grade IIB—III were enrolled. 40 patients underwent open aorto-femoral-popliteal repair (group A) and 40 patients — medication (group B). Before and in 3 months after surgery peripheral venous blood samples were collected to assess the activity of factors VIII, IX, XI, von Willebrand factor (VWF), protein C (PrC), and metabolites of nitric oxide II (NO). Results. Increased preoperative activity of VIII, IX, XI, and VWF factors compared with normal values was observed in group A. After 3 months there was an additional increase of VIII and VWF factors’ activity. Activity of IX and XI factors remained increased on background of reduced level of NO metabolites. In group B increased activity of IX, XI, and VWF factors was revealed while levels of NO metabolites and PrC were normal. Conclusion. Thus, PAD is followed by prothrombotic state especially in patients after surgery. Surgical procedures are associated with more severe hypercoagulation.

Keywords:

atherosclerosis
intrinsic coagulation pathway
hemostatic markers of endothelial dysfunction

Authors:

Kalinin R.E.

I.P. Pavlov Ryazan State Medical University, Ryazan

Suchkov I.A.

I.P. Pavlov Ryazan State Medical University, Ryazan

Mzhavanadze N.D.

Pavlov Ryazan State Medical University of Ministry of Health of Russia, Ryazan, Russia

Demikhov V.G.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

Zhurina O.N.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

Klimentova E.A.

Pavlov Ryazan State Medical University of Healthcare Ministry of Russia, Ryazan, Russia

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References:

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