It was performed the retrospective analysis of radical mastectomy results in 6994 patients with verified mammary gland cancer. The first group included 3957 patients after developed wound closure during radical mastectomy. It was used improved method of wound suturing in 2037 patients of the second group. The control group included 1000 patients after radical mastectomy for Madden with installation of drainage system. It was concluded that wound suturing without drainage system installation significantly decreases the frequency and severity of lymphorrhea, length of hospital stay. It is not necessary to use expensive materials such as polymers, adhesives, gels and optional equipment in case of wound suturing without drainage system installation. Initial technique improvement provided more pronounced positive results such as significantly decreasing of frequency, severity and duration of lymphorrhea, reduction of hospital stay length.