Survival data of patients with multifocal breast cancer in dependence on surgical resection volume were analyzed. Two types of surgery were performed: the modified radical mastectomy by Madden and radical resection of the mammary gland. It was stated, that organ-preserving operation in combination with complex adjuvant therapy of the multifocal breast cancer stage I-II did not lead to the decrease of the overall and recurrence-free 5 and 10-year survival rate.