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Patiutko Iu.I.

Blokhin National Medical Research Center of Oncology

Chuchuev E.S.

Khirurgicheskoe otdelenie opukholeĭ pecheni i podzheludochnoĭ zhelezy Rossiĭskogo onkologicheskogo nauchnogo tsentra im. N.N. Blokhina RAMN, Moskva

Podluzhnyĭ D.V.

Rossiĭskiĭ onkologicheskiĭ nauchnyĭ tsentr im. N.N. Blokhina RAMN, Moskva

Agafonova M.G.

Khirurgicheskoe otdelenie opukholeĭ pecheni i podzheludochnoĭ zhelezy Nauchno-issledovatel'skogo instituta klinicheskoĭ onkologii Rossiĭskogo onkologicheskogo nauchnogo tsentra im. N.N. Blokhina RAMN, Moskva

The possibilities of surgical treatment of hepatocellular cancer in patients with liver cirrhosis

Authors:

Patiutko Iu.I., Chuchuev E.S., Podluzhnyĭ D.V., Agafonova M.G.

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Journal: Pirogov Russian Journal of Surgery. 2011;(10): 13‑19

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THE POSSIBILITIES OF SURGICAL TREATMENT OF HEPATOCELLULAR CANCER IN PATIENTS WITH LIVER CIRRHOSIS
THE POSSIBILITIES OF SURGICAL TREATMENT OF HEPATOCELLULAR CANCER IN PATIENTS WITH LIVER CIRRHOSIS

To cite this article:

Patiutko IuI, Chuchuev ES, Podluzhnyĭ DV, Agafonova MG. The possibilities of surgical treatment of hepatocellular cancer in patients with liver cirrhosis. Pirogov Russian Journal of Surgery. 2011;(10):13‑19. (In Russ.)

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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154 radical liver resections were performed on the reason of the hepatocellular cancer, of them 33% in patients with liver cirrhosis. Liver function was assessed using the Child-Pugh score. Liver cirrhosis and extensive liver resections proved to be the independent complication and lethality risk factors. The extensive liver resections were performed in 70%. The postoperative morbidity rate was 44.8%, the lethality was 5.8%. The concomitant liver cirrhosis reliably worsens postoperative complications (p=0.001) and lethality (p=0.0001) rates. The long-term treatment results were analyzed. Thus, liver resection proved to be an appropriate treatment for patients with hepatocellular cancer and liver cirrhosis Child-Pugh stage A, but a thorough patient selection is recommended. Liver resection is contraindicated by liver cirrhosis Child-Pugh stage B. The orthotopic liver transplantation is recommended in such cases, considering that Milan criteria are observed. The rest cases should consider the possibilities of radiofrequency ablation, transarterial chemoembolization, chemotherapy.

Keywords:

hepatocellular cancer
liver cirrhosis
liver resection

Authors:

Patiutko Iu.I.

Blokhin National Medical Research Center of Oncology

Chuchuev E.S.

Khirurgicheskoe otdelenie opukholeĭ pecheni i podzheludochnoĭ zhelezy Rossiĭskogo onkologicheskogo nauchnogo tsentra im. N.N. Blokhina RAMN, Moskva

Podluzhnyĭ D.V.

Rossiĭskiĭ onkologicheskiĭ nauchnyĭ tsentr im. N.N. Blokhina RAMN, Moskva

Agafonova M.G.

Khirurgicheskoe otdelenie opukholeĭ pecheni i podzheludochnoĭ zhelezy Nauchno-issledovatel'skogo instituta klinicheskoĭ onkologii Rossiĭskogo onkologicheskogo nauchnogo tsentra im. N.N. Blokhina RAMN, Moskva

List of references:

  1. Bilimoria M.M., Lauwers G.Y., Doherty D.A. et al. Underlying liver disease, not tumour factors, predicts long-term survival after resection of hepatocellular carcinoma. Arch Surg 2001; 136: 528-535.
  2. Capussotti L., Muratore A., Amisano M. et al. Liver resection for hepatocellular carcinoma on cirrhosis: analysis of mortality, morbidity and survival-a European single center experience. EJSO 2005; 31: 986-993.
  3. Chen X.P., Qiu F.Z., Wu Z.D., Zhang Z.X. Chinese experience with hepatectomy for huge hepatocellular carcinoma. Br J Surg 2004; 91: 322-326.
  4. Fong Y., Sun R.L., Jarnagin W., Blumgart L.H. An analysis of 412 cases of hepatocellular carcinoma at a Western center. Ann Surg 1999; 229: 790-799.
  5. Grazi G.L., Cescon M., Ravaioli M. et al. Liver resection for hepatocellular carcinoma in cirrhotics and noncirrhotics. Evaluation of clinicopathologic features and comparison of risk factors for long-term survival and tumour recurrence in a single centre. Aliment Pharmacol Ther 2003; 17: 119-129.
  6. Ikai I., Arii S., Kojiro M. et al. Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese Nationwide survey. Cancer 2004; 101: 796-802.
  7. John A.R., Khan S., Mirza D.F. et al. Multivariate and univariate analysis of prognostic factors following resection in HCC: the Birmingham experience. Dig Surg 2006; 23: 103-109.
  8. Jonas S., Bechstein W.O., Steinmüller T. et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33: 1080-1086.
  9. Kanematsu T., Furui J.,Yanaga K. et al. A 16-year experience in performing hepatic resection in 303 patients with hepatocellular carcinoma: 1985-2000. Surgery 2002; 131: 153-158.
  10. Knight S., Friend P., Morris P. Role of transplantation in the management of hepatic malignancy. Br J Surg 2007; 94: 1319-1330.
  11. Mazzaferro V., Regalia E., Doci R. et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996; 334: 693-699.
  12. Montorsi M., Santambrogio R., Bianchi P. et al. Survival and recurrences after hepatic resection or radiofrequency for hepatocellular carcinoma in cirrhotic patients: a multivariate analysis. J Gastrointest Surg 2005; 9: 62-67.
  13. Morris-Stiff G., Gomez D., Liguori Carino N., Prasad K. Surgical management of hepatocellular carcinoma: Is the jury still out? Surgical Oncology 2009; 18: 298-321.
  14. Nadig D.E., Wade T.P., Fairchild R.B. et al. Major hepatic resection. Indications and results in a national hospital system from 1998 to 1992. Arch Surg 1997; 132: 115-119.
  15. Ng K.K., Vauthey J.N., Pawlik T.M. et al. Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multiinstitutional database. Ann Surg Oncol 2005; 12: 364-373.
  16. Okuda H. Hepatocellular carcinoma development in cirrhosis. Res Clin Gastroenter 2007; 1: 161-173.
  17. Schwartz M., Roayaie S., Konstadoulakis M. Strategies for the management of hepatocellular carcinoma. Nat Clin Pract Oncol 2007; 4: 7: 424-432.
  18. Teh S.H., Christein J., Donohue J. et al. Hepatic resection of hepatocellular carcinoma in patients with cirrhosis: model of end-stage live disease (MELD) score predicts perioperative mortality. J Gastrointest Surg 2005; 9: 1207-1215.
  19. Wayne J.D., Lauwers G.Y., Ikai I. et al. Preoperative predictors of survival after resection of small hepatocellular carcinomas. Ann Surg 2002; 235: 722-731.
  20. Wu C.C., Cheng S.B., Ho W.M. et al. Liver resection for hepatocellular carcinoma in patients with cirrhosis. B J Surg 2005;92:348-355.
  21. Yamamoto J., Okada S., Shimada K. et al. Treatment strategy for small hepatocellular carcinoma: comparison of long-term results after percutaneous ethanol injection therapy and surgical resection. Hepatology 2001; 34: 707-713.
  22. Yedibela S., Förtsch T., Hohenberger W., Meyer T. Liver transplantation for hepatocellular carcinoma: a single European experience. Langenbecks Arch Surg 2004; 389: 104-109.
  23. Zavaglia C., De Carlis L., Alberti A.B. et al. Predictors for long-term survival after transplantation for hepatocellular carcinoma. Am J Gastroentreol 2005; 100: 2708-2716.

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