Treatment results were analyzed in 197 patients with pancreonecrosis. After admission to hospital their clinical course was predicted as non-severe according to APACHE II score (less than 8 points). It is estimated that body temperature lower than 36.6°C, marked abdominal swelling, level of consciousness less that 15 points according to Glasgo scale, leukocytosis higher than 18·109, lymphopenia less than 18%, hypoproteinemia less than 60g/l and presence of portal hypertension are risk factors for lethal outcome in patients with predictable mild clinical course of necrotic pancreatitis. Authors suggest that patients with initially mild clinical course of pancreonecrosis in presence of risk factors must receive the same treatment as patients in poor state.